
Definisse Filler
When talking about filler brands approved by the Thai FDA and available in aesthetic clinics, there are currently many options. These include products from Europe, the United States, Korea, and most recently, Definisse Filler from Italy. This filler is also certified by the Thai FDA, making it another option for those seeking facial rejuvenation, wrinkle reduction, correction of deep lines, or contour enhancement.
How is Definisse filler different from other brands? Which areas is it suitable for? You can explore these details in this article before making your decision.
Table of content : Definisse Filler
What is Definisse Filler?

Definisse Filler is an imported filler from Italy, formulated with Hyaluronic Acid (HA). Similar to other well-known fillers such as Restylane, Juvederm, and Belotero, it is considered safe, naturally dissolves over time, and leaves no harmful residue in the body.
Today, Definisse Filler is gaining worldwide recognition and is used in many countries. It is manufactured by Relife Company, a subsidiary of A. Menarini in Italy, and distributed in Thailand by A. Menarini Thailand.
Currently, Definisse Filler is available in four versions: Core, Restore, Touch, and Hydrobooster. Among these, three versions — Core, Restore, and Touch — are approved by the Thai FDA (THFDA).
These three certified types have different molecular densities, making them suitable for different treatment indications and injection sites on the face.
Which areas is Definisse Filler suitable for?
Filler injections can be applied to various parts of the face to correct wrinkles, soften deep folds, and enhance facial contours for a more youthful appearance. Common treatment areas include:
- Under-eye filler – Reduces hollowness and dark circles.
- Temple filler – Improves sunken temples and balances facial structure.
- Lip filler – Enhances lip volume and definition.
- Forehead filler – Smooths wrinkles and creates a youthful contour.
- Nose filler – Refines nasal shape without surgery.
- Cheek filler – Restores volume in hollow or sunken cheeks.
At V Square Clinic, we use three versions of Definisse Filler depending on treatment goals:

- Definisse Restore – A soft filler with moderate firmness, designed to correct deep wrinkles and folds caused by aging. Commonly used for nasolabial folds and marionette lines. Results typically last up to 12 months.
- Definisse Core – A firmer filler with higher density, suitable for bone support and facial contouring. Commonly used for chin augmentation and jawline contouring. Results typically last up to 18 months.
- Definisse Touch – A soft yet well-structured filler with a smooth texture. Ideal for delicate areas such as under the eyes, nasolabial folds, marionette lines, and lips. Results usually last 8–12 months.
How is Definisse Filler different from other fillers?
Definisse Filler, like other well-known brands, is based on Hyaluronic Acid (HA). However, what makes it stand out is its unique production process, known as XTR™ Technology (eXcellent Three-Dimensional Reticulation).
This technology enhances the cross-linking of Hyaluronic Acid into a strong three-dimensional matrix, providing natural-looking support and contouring. The process involves three carefully controlled steps:
- Pretreatment – HA molecules are prepared and structured into two types:
- Low molecular weight
- High molecular weight
- Cross-linking – Enhances HA stability, enabling smoother injection, easier handling for doctors, and precise correction of problem areas. Results look natural and integrate seamlessly with facial tissue.
- Purification – Removes residual BDDE (a chemical used in cross-linking) that may otherwise cause allergic reactions. This results in a highly purified HA filler, reducing the risk of swelling. Downtime is minimal, and most patients experience little to no swelling.

What are the properties of Definisse Filler?
Definisse Filler is formulated to restore volume, lift, and contour the face effectively. One of its key advantages is that it does not cause water retention after injection, allowing the results to be assessed immediately during the procedure. When injected with proper technique and in the right amount (optimal volumization), patients can see instant improvements that look natural.
Another feature is the Innovative Glass Syringe, made from premium-quality glass and designed to deliver low injection pressure. This enables doctors to inject with greater precision and lowers treatment risks. Glass syringes also minimize plastic contamination that may trigger allergic reactions in some patients, while at the same time contributing to reduced plastic usage.

Who is Definisse Filler suitable for?
- Individuals who want to enhance facial contours and add dimension to their features.
- Those who want to correct tired-looking skin, dryness, or dullness.
- People experiencing a loss of skin elasticity and firmness who need tighter, more lifted skin.
- Patients with wrinkles or deep lines who want to restore a youthful appearance.
- Anyone seeking overall skin improvement for a plumper and more hydrated look.
Can Definisse Filler be combined with other treatments?
Yes, Definisse Filler can be combined with other aesthetic procedures. Treatments such as Botox, thread lifts, and skin tightening devices like Hifu, Ulthera, and Thermage can be safely performed together.
At V Square Clinic, our doctors carefully assess each patient’s skin condition and recommend the most suitable treatment combinations to achieve natural, long-lasting results tailored to individual needs.
Contraindications and preparation guidelines for Definisse Filler
To achieve the best and safest results, patients should be aware of certain contraindications and pre-treatment guidelines before receiving Definisse Filler.
Contraindications for Definisse Filler
- Individuals allergic to Hyaluronic Acid (HA).
- Pregnant or breastfeeding women.
- Patients with active skin conditions such as herpes or shingles.
Pre-treatment guidelines
Before receiving Definisse Filler, patients should prepare as follows:
- Research essential information: choose a certified clinic, verify the doctor’s credentials, review filler techniques, and understand how to identify genuine fillers.
- Discontinue exfoliating creams, aspirin, and NSAIDs (e.g., ibuprofen, diclofenac, ponstan) for 1 week before the procedure.
- Stop taking supplements such as St. John’s Wort, ginkgo biloba, primrose oil, garlic, ginseng, and Vitamin E for 1 week before treatment.
- Avoid alcohol for at least 24 hours before injection.
- Refrain from intense activities that increase blood circulation.
- If you have chronic medical conditions or are taking regular medication, inform your doctor beforehand.
- Ensure you are not allergic to HA, not pregnant or breastfeeding, and do not have bleeding disorders. After reviewing your medical history, if no issues are found, treatment can proceed immediately.
Results after Definisse Filler injections
Results are visible immediately after treatment. Improvements become more noticeable over time, and the effects generally last 12–18 months, depending on the version of Definisse Filler used.
How much does Definisse Filler cost?
The price of Definisse Filler depends on the version, the amount used, and the injection technique required for each treatment area. Prices typically start at 12,000 THB per 1 cc and may vary based on individual needs and goals.
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Where is the best place to get Definisse filler injections?
Before deciding where to receive filler injections, patients should gather essential information. For example, knowing which filler brands are approved by the Thai FDA and how to check for authentic products helps ensure that only genuine, high-quality fillers are used.
It is also important to evaluate the clinic. Key points to look for include:
- The clinic must meet safety and quality standards, be licensed by the Ministry of Public Health, display an 11-digit license number, and have a clear signboard in a visible location such as a shopping mall or commercial building.
- Treatments must be performed by licensed doctors with experience in filler injections. This ensures safe, natural results without lumps, swelling, or bruising. Patients can verify the doctor’s name through the Medical Council of Thailand. Ideally, choose a doctor with extensive filler experience.
- All fillers must be authentic and brand-certified. The doctor should open a new filler box in front of the patient, ensuring it comes directly from an authorized distributor. The doctor should also assess your needs and recommend the most suitable filler brand.
- Clinics should have reviews from credible and unbiased sources that cannot be altered by the clinic itself, such as Facebook Reviews or Pantip.
At V Square Clinic, we provide services across Bangkok and surrounding areas, with a team of highly experienced doctors specializing in facial contouring using fillers. Our doctors apply the Fine Art of Filler technique, focusing on safety and natural-looking results.

All filler brands used at our clinic are authentic, globally recognized, and FDA-approved. If patients are not satisfied with the results, the filler can be safely dissolved without residue. After every procedure, follow-up care is provided for each patient. There are no sales agents involved — only professional consultation and personalized treatments tailored to each individual’s skin condition and concerns.
Conclusion
Definisse Filler is an excellent option for those who want to rejuvenate their appearance and enhance facial contours. For best results, patients should consult with a trusted doctor and receive treatment at a certified clinic that uses only genuine Definisse Filler. This ensures natural, safe, and long-lasting results.
Reference
- Definisse filler
https://relifecompany.co.uk/uploads/ReLife-online-brochure-FILLERS-3-cert-2-Jan-21.pdf
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