Rejuran – Skin Rejuvenation Innovation with Salmon DNA
Rejuran is a medical aesthetic innovation that rejuvenates the skin and enhances skin texture and clarity. It is clinically proven, certified by the Thai FDA, and supported by multiple scientific studies. Its popularity has grown significantly in recent years, especially among those desiring radiant, glass-like Korean skin.
If you’re interested in Rejuran injections, this article provides everything you need to know, based on published studies and clinical experience: What is Rejuran? How does it work? Who is it best for? When will you see results? How many sessions are needed? What are the differences between Rejuran and Skin Boosters? How long does it last? By the end of this guide, you’ll know whether Rejuran is right for your skin goals.
Table of Content : Rejuran
What Is Rejuran?
Rejuran is a type of skin booster in the mesotherapy category. Its key active ingredient is Polynucleotide (PN), a purified, high-concentration extract derived from salmon DNA—sharing over 98% similarity with human DNA. When injected into the dermis, it strengthens the skin, reduces fine lines, and improves skin tone and radiance rapidly.
How Rejuran Works
Rejuran restores youthful skin quality by injecting highly purified Polynucleotides that are naturally biocompatible. This process, known as rejuvenation, helps replace damaged skin cells and regenerate new, healthy ones.
One key property of Polynucleotides is their ability to reconnect microvessels in skin tissue, repairing damage and reducing inflammation. They also stimulate growth factors and fibroblast cells, which are responsible for producing collagen and elastin, resulting in stronger, hydrated, and naturally glowing skin.
Why Are Polynucleotides (PN) in Rejuran So Effective?
To help you understand this better, here’s a closer look at Polynucleotides (PN), commonly known as salmon DNA:
- PN is a gel-like, clear solution extracted from wild salmon using patented DOT™ technology.
- It is highly purified, antigen-free, and non-immunogenic, making it safe for human skin without causing adverse reactions.
- It integrates seamlessly into the skin and gradually repairs tissue damage.
- PN boosts skin elasticity by supporting the skin’s natural regenerative processes in both the dermis and epidermis.
Note: Salmon DNA closely resembles human DNA. The PN used in Rejuran comes specifically from salmon reproductive cells (scientifically known as salmon sperm cells). After going through a rigorous purification process that eliminates antigens and proteins that might trigger immune responses, it becomes extremely safe for use.
Interestingly, studies show that PN also accelerates healing in diabetic wounds and helps repair pigmentation issues, scar tissue, and inflammatory skin conditions.
What Can Rejuran Help With?
- Skin Repair: Strengthens the skin from within, improving conditions caused by aging such as fine lines, under-eye wrinkles, neck creases, acne scars, enlarged pores, redness, and discoloration.
- Improved Elasticity: Encourages new collagen synthesis, reinforcing dermal structure, improving skin elasticity, and minimizing fine lines.
- Even Skin Tone: Enhances brightness, reduces acne marks, evens out skin tone, and gives a hydrated, glass-skin glow.
Who Is Rejuran Suitable For?
Rejuran penetrates the dermal layer, making it suitable for:
- Anyone seeking natural-looking, healthy, smooth skin
- Individuals in their late 20s who are starting to experience dull or dry skin
- Those aiming to improve skin texture and reduce wrinkles
- People looking to prevent acne, balance their skin, and refine pores
- Anyone with sun-damaged skin wanting a brighter, more even tone, and reduced dark spots or pigmentation
How Many Rejuran Sessions Are Needed, And When Will You See Results?
The full effects of Rejuran’s skin-repairing action are typically seen after 4 weeks. A recommended protocol is 4 sessions, spaced 2–3 weeks apart.
- Session 1 (3–5 days): Skin becomes softer, more hydrated, and smoother.
- Session 2 (2–4 weeks): Increased firmness, reduced wrinkles, and tighter pores.
- Session 3 (4–6 days): Skin appears lifted, firmer, and stronger.
- Session 4 (6–8 days): Visible improvements in firmness, even tone, reduced wrinkles, and balanced skin health.
After completing 4 sessions, maintenance can be done every 3–6 months to maintain youthful-looking skin.
Is Rejuran Approved by the Thai FDA?
Rejuran Skin Booster formulas used in treatments include Rejuran Healer and Rejuran Rejuvenation (PN). Commonly referred to as the “black box” or “classic” Rejuran, these formulations were developed and manufactured in South Korea and are officially approved by both the Korean FDA (KFDA) and Thailand’s FDA (since 2022).
How Many Types of Rejuran Are There?
- Rejuran Healer (Black Box / Rejuran Classic): This popular skin booster helps rejuvenate the skin, improve hydration, refine pores, and increase elasticity. Its medium-viscosity gel makes it suitable for full-face treatments, the neck, and the backs of the hands.
- Rejuran i (White Box): Specially designed for delicate under-eye and mouth areas, Rejuran i has a thinner gel for precision targeting of fine lines and dark circles.
- Rejuran S (Blue Box): Intended for acne scars and skin texture issues. Rejuran S has the highest viscosity, allowing it to stay longer in the treated area for effective tissue repair and scar smoothing.
- Rejuran HB Plus (Red Box): Combines PN, Hyaluronic Acid (HA), and Lidocaine for immediate hydration and comfort during treatment. Ideal for use on the face, neck, and hands.
Selecting the right formula depends on your specific skin concerns. Consult a trained aesthetic doctor to ensure safety and optimal results.
Where Can Rejuran Be Injected?
Rejuran is most frequently used to rejuvenate the face, but it is also effective for other areas that show signs of aging:
- Face: Can be applied to the entire facial area such as around the eyes, forehead, cheeks, smile lines, and under the eyes.
- Neck: Enhances hydration and reduces lines, especially popular among patients aged 40 and above.
- Hands: Treats dryness and dullness, making hands appear healthier and more youthful.
How Many CCs of Rejuran Are Needed per Treatment?
Rejuran Healer is measured in milliliters (ml), where 1 ml equals 1 cc. Each box contains two syringes of 2.7 ml, totaling 5.4 ml. Typical usage per session is as follows:
- Full face: 4 ml
- Cheek area only: 2 ml
- Neck or hands: 2 ml
Does Rejuran Injection Hurt?
Rejuran injections feel similar to mesotherapy treatments. Patients may experience mild stinging as the product is injected, but this can be minimized with cold compresses.
One benefit of Rejuran is its ultra-fine needle, which allows the gel to pass through smoothly, enhancing absorption while reducing discomfort. It also minimizes post-injection marks.
Precautions Before Getting Rejuran Treatment
As with any aesthetic procedure, patients should fully understand what the treatment involves. Consultation with a qualified doctor is essential to determine whether Rejuran is suitable for their specific concerns.
Safety precautions
- Always receive treatment from a certified doctor with experience in facial anatomy.
- Avoid treatment if taking NSAIDs, anticoagulants, or immune-suppressing drugs.
- Stop taking supplements such as primrose oil, garlic, ginseng, or vitamin E at least 1 week before the procedure.
- Not suitable for individuals with autoimmune diseases, sarcoidosis, or endocarditis.
- Do not overuse or inject excessive volumes.
- Not recommended for those allergic to sodium polynucleotide (PN).
- Contraindicated for pregnant or breastfeeding women.
- Avoid injecting into inflamed or infected skin.
- Not advised for those with seafood allergies.
Rejuran Injection Procedure
During a Rejuran treatment, the doctor uses a fine needle to inject the solution into strategic points on the face. (A numbing cream or cold compress can be applied beforehand for patients concerned about pain.) After the injection, slight swelling may occur at the injection sites, but this usually subsides within 1–2 hours. Patients can resume normal activities immediately without any downtime.
Post-Injection Care for Rejuran
After a Rejuran treatment, patients can generally resume daily activities as normal. However, following these care guidelines will help optimize results:
- Wash your face with gentle cleansers or plain water.
- Avoid rubbing or scrubbing to minimize irritation.
- Refrain from applying makeup for at least 24 hours to prevent contamination at injection sites.
- Use skincare products as normal.
- Avoid alcohol, which dehydrates the skin, and reduce smoking, as it can lead to dullness.
- Drink plenty of water to maintain hydration and skin glow.
- Apply a cold compress if redness or bruising occurs, as advised by your doctor.
- Take pain relief medication if tenderness occurs at injection sites on the first night.
- Stay in a cool environment to help reduce swelling more quickly.
Rejuran Compared to Other Brands
There are many brands of mesotherapy for skin brightening, each with its own unique benefits depending on the ingredients. Here are the key features of each brand:
- MADE Collagen: Contains a blend of ingredients that help reduce acne, rashes, and inflammation while detoxifying the skin. It is ideal for restoring skin health and strengthening the skin barrier.
- Filorga / Revs: Focuses on evening out skin tone and texture, enhancing moisture retention, and strengthening the skin.
- Tensonez / Depigment: Suitable for those wanting brighter, clearer skin. The solution causes minimal stinging and shows quick results. For treatments targeting melasma and dark spots, it may sting more but is highly effective.
- Alpha Arbutin: Specifically targets melasma reduction, though it causes significant stinging.
- Neo Glutanex Glow: Brightens the skin to a rosy-white tone while hydrating, reducing wrinkles, melasma, freckles, and acne scars, and tightening pores.
- Exosome: Rejuvenates and improves overall skin quality, resulting in clearer, hydrated, and healthy-looking skin. Suitable for those with melasma, freckles, dark spots, acne marks, enlarged pores, or dry and dehydrated skin.
There are also collagen biostimulators that rejuvenate the skin by injecting ingredients into the dermis to trigger collagen production. These are ideal for individuals aged 20 and older seeking youthful, firm skin:
- Gouri: Uses PCL (Polycaprolactone) in a fully liquid form that dissolves completely without residue. It is safe for dermal injection and known for repairing aging skin sustainably and restoring a youthful glow.
- Sculptra: Made of Poly-L-Lactic Acid (PLLA), which stimulates collagen type I production to replace what is lost with age. It firms the skin, boosts elasticity, and rebuilds dermal structure for long-lasting, natural rejuvenation.
- Radiesse Filler: Although a filler, it contains CaHA (Calcium Hydroxylapatite microspheres), which strengthens deep skin layers and stimulates new collagen formation. It tightens the skin, reduces wrinkles, and enhances skin quality over time.
This comparison helps patients understand how Rejuran differs from other treatments, aiding in making an informed choice.
How Is Rejuran Different from Skin Boosters?
Rejuran Healer is a skin rejuvenation treatment that shares a similar purpose with skin boosters but works differently:
- Skin Boosters contain Hyaluronic Acid (HA) and are injected into the superficial skin layer to hydrate and smooth fine lines.
- Rejuran Healer contains PN (DNA Nucleotide), targeting anti-aging at the cellular level by repairing and revitalizing damaged skin.
In short, Skin Boosters and Rejuran function differently. Combining both treatments may enhance results. However, because both retain water, spacing between sessions is recommended to avoid facial puffiness.
How to Identify Genuine Rejuran
How to Spot Authentic Rejuran:
- Look for the hologram sticker on the box
- Scanning the QR code redirects to the verification page
- Includes Thai FDA-approved labeling
- Each Rejuran Healer box contains two syringes and 33G needles for intradermal injection
How Much Does Rejuran Cost?
Rejuran treatments typically start at around 10,000 THB per syringe, depending on the clinic’s promotion and dosage needed. The doctor will assess skin condition and recommend a personalized plan. Patients may choose full or staged treatments based on their budget.
Interested in getting Rejuran at V Square Clinic?
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Where to Get Rejuran Injections?
If you’re deciding where to get Rejuran, safety should be your top priority. Here are three essential factors to consider:
- Certified Clinics: Ensure the clinic has an 11-digit license and is legally authorized.
- Experienced Doctors: Choose a clinic with on-site, experienced doctors.
- Authentic Products: The clinic should unbox the product in front of you to confirm it’s genuine.
At V Square Clinic, we offer multiple Skin Booster formulations tailored to different skin types. Our doctor will assess your condition and recommend the best formula for your needs.
Rejuran FAQs
1. Will Rejuran Cause Facial Swelling?
Mild swelling or bumps may occur from the injections, typically resolving in 3–5 days without concern.
2. Can I Wear Makeup After Rejuran?
Avoid wearing makeup for at least 24 hours after treatment, as the injection sites may be vulnerable to infection.
3. What’s the Best Rejuran Injection Method?
There are different injection methods—device-assisted or manual. Manual injection is preferred, as Rejuran is designed to be injected point by point with a spacing of 0.5 cm for optimal dispersion and results.
4. Is It Safe to Mix Rejuran with Mesotherapy?
Mixing is not recommended. Some patients have experienced allergic reactions when combining Rejuran with meso solutions. It’s safer to inject them separately.
5. Can Rejuran Be Combined with Laser Treatments?
Yes, but not in the same session. Heat from lasers or tightening treatments like HIFU, Ulthera, or Thermage can increase inflammation. A gap of 2–4 weeks is advised.
6. How Long Does Rejuran Last?
Results typically last 6–8 months, depending on skin condition and aftercare. Sun protection, hydration, and proper skincare can prolong the effects.
7. Are There Any Side Effects?
Some may experience pain during injection, as Rejuran is delivered into the mid-dermis. Numbing cream helps reduce discomfort. Swelling or redness may occur but resolves in 2–3 days.
Summary – Is Rejuran Worth It?
Rejuran Healer helps restore and repair skin from within safely and effectively. It stimulates collagen and elastin production, deeply hydrates, and combats signs of aging—perfect for those seeking long-term youthful skin.
Reference
- https://www.researchgate.net/publication/269416487_A_Phase_III_Randomized_Double-Blind_Matched-Pairs_Active-Controlled_Clinical_Trial_and_Preclinical_Animal_Study_to_Compare_the_Durability_Efficacy_and_Safety_between_Polynucleotide_Filler_and_Hyaluron
- Pharma Research Product Rejuran (파마리서치프로덕트_리쥬란4종통합브로셔(영문)_최종)
- OakBend Medical Center. (2024). What is a Diabetic Ulcer? Retrieved from https://oakbendmedcenter.org/what-is-a-diabetic-ulcer/ (Accessed on March 31, 2025).
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