Sculptra – A Collagen-Stimulating Innovation
Sculptra is an advanced skin rejuvenation treatment that works from within by boosting collagen production. It restores firmness and smoothness to aging or sagging skin, offering a youthful appearance. This method is becoming increasingly popular for addressing age-related skin concerns such as wrinkles and volume loss.
This article explains everything you need to know about Sculptra—what it is, how it works, its safety, who it is suitable for, the cost, and how it compares to other collagen-stimulating treatments. It also discusses the pros and cons to help you make an informed decision.
Table of Content : Sculptra
What is Sculptra?
Sculptra contains microparticles of poly-L-lactic acid (PLLA), recognized as the world’s first natural collagen biostimulator. Its primary function is to stimulate collagen production within the skin, replenishing what is lost with age. As a result, it helps create firmer, plumper, and more elastic skin, restores structure from the deeper layers, and yields natural-looking results.
Sculptra has been used in medical treatments since 1999 and is backed by over 50 research studies. It is FDA-approved in the U.S. and developed by Galderma Laboratories, L.P.
The PLLA microparticles in Sculptra are produced using Galderma’s patented technology, forming a safe and effective compound called PLLA-SCA for injection.
What is Collagen and Why Is It Important?
Before exploring Sculptra further, it is important to understand the role of collagen in the skin.
Collagen is a structural protein found in connective tissues like skin, tendons, and blood vessels. In skin alone, collagen makes up about 75% of the structure and accounts for one-third of all proteins in the body. It plays a crucial role in maintaining skin elasticity, strength, and moisture retention.
There are 5 main types of collagen:
- Type I: The most abundant type, found in skin, tendons, and blood vessel walls. It provides strength and elasticity and helps maintain skin smoothness.
- Type II: Found in cartilage (ears, ribs, trachea). It supports joint movement and absorbs impact.
- Type III: Works alongside Type I, found in skin, muscles, and blood vessels.
- Type IV: Found in the basement membrane of organs, supporting tissue function and nutrient exchange.
- Type V: Found in cell linings such as the cornea and placenta. It helps with cellular arrangement and skin fiber formation.
Natural collagen production gradually decreases after the age of 25, at a rate of about 1.5% per year. This decline results in visible signs of aging—wrinkles, dryness, and sagging. Without proper care, deeper wrinkles can develop over time.
How Does Sculptra Work?
Sculptra uses Poly-L-Lactic Acid (PLLA), a biocompatible and biodegradable substance approved by the U.S. FDA for collagen stimulation.
Before injection, Sculptra is mixed with sterile water. After treatment, the treated area appears plump due to the added hydration. This temporary fullness lasts for about 2–3 days as the water is gradually absorbed, revealing its underlying collagen-stimulating action.
Sculptra activates the immune system, prompting fibroblasts (collagen-producing cells) to increase in number and activity. According to studies, Sculptra can boost collagen production by up to 66.5%. As collagen builds, the skin becomes firmer, plumper, and structurally stronger.
Over time, the PLLA is naturally broken down and absorbed by the body, leaving behind newly formed collagen. The results of lifted, rejuvenated skin can last up to 2 years.
How Does Sculptra Compare to Other Treatments?
Many injectable treatments aim to reduce wrinkles and improve skin quality. This section compares Sculptra with other popular options.
Sculptra vs. Dermal Fillers
Dermal fillers, especially those made of Hyaluronic Acid (HA), are commonly used to add volume and hydration to areas of the face such as the temples, cheeks, and chin. Results are immediate and typically last 6 to 24 months, depending on the product.
Some fillers, like Skin Boosters, are designed to hydrate the skin and improve texture across the entire face, or to treat acne scars.
Unlike fillers, Sculptra doesn’t simply add volume—it stimulates the skin to produce its own collagen. Results appear gradually, starting at 3 weeks, becoming more visible around 3 months, and can last up to 25 months.
Sculptra vs. Mesotherapy (Skin Boosting)
Mesotherapy involves injecting beneficial vitamins and extracts into the skin to reduce acne, pigmentation, or dryness. Options include MADE Collagen, Tensonez, and Filorga. While effective for brightening and hydration, results typically last 2-3 months and require frequent sessions.
Sculptra, on the other hand, offers longer-lasting benefits by promoting collagen production deep within the skin. It can be combined with mesotherapy depending on individual skin needs.
Sculptra vs. Rejuran
Rejuran contains Polynucleotide (PN), derived from salmon DNA, which is similar to human DNA. It promotes fibroblast activity, aiding skin repair, strengthening the skin barrier, and refining pores.
Sculptra uses plant-based PLLA with minimal allergy risk and no residue. It’s ideal for those seeking volume, firmness, and long-term wrinkle reduction.
Sculptra vs. Gouri
Both are collagen biostimulators, but Gouri uses PCL (Polycaprolactone) in liquid form, while Sculptra uses powdered PLLA. Sculptra results last longer, approximately 2 years, compared to Gouri, which lasts about 1 year.
Sculptra vs. Exosome
Exosomes are tiny biomolecules rich in peptides, enzymes, hyaluronic acid, and proteins. They are quickly absorbed into skin cells and promote surface-level repair, improving brightness and reducing dark spots.
Sculptra, on the other hand, works on deeper layers, lifting and firming the skin by enhancing structural collagen.
Who Is a Good Candidate for Sculptra?
- Individuals experiencing sagging or loss of skin elasticity
- Those with visible wrinkles and age-related fine lines
- People whose skin has been neglected and needs structural restoration
- Anyone seeking long-lasting volume, firmness, and rejuvenation
- Those who prefer a long-lasting result without frequent touch-ups (Sculptra can last up to 2 years)
What Can Sculptra Help With?
- Rebuilding the skin’s internal structure for increased resilience
- Lifting and firming sagging skin
- Reducing deep wrinkles and folds naturally
- Smoothing out fine lines for a tighter, more youthful texture
- Improving hydration and enhancing overall radiance
Sculptra Results and Reviews
Sculptra is commonly used to rejuvenate facial skin, but it can also be applied to the body—such as the abdomen, upper arms, thighs, and buttocks—based on patient concerns.
Results vary based on individual skin conditions and treatment areas. When performed by a well-trained physician certified by Galderma, patients often see noticeable improvements from the first session.
Here are some real patient cases treated at V Square Clinic
1 vial of Sculptra combined witCC of facial/under-eye filler3 CC for jawline and chin, and 1 CC for lips.
4 vials of Sculptra with follow-up results after 2 months.
*Results are based on individual patient care.
Sculptra Injection Procedure
- Consultation and assessment: The procedure begins with a skin analysis and consultation with the physician to assess concerns and determine suitability.
- Numbing preparation: A numbing cream is applied to the target area for approximately 45 minutes.
- Sculptra preparation: During the numbing period, the physician prepares Sculptra in its active form by mixing it with sterile water.
- Injection: Sculptra is injected into the subdermal layer (1.5–2 cm deep) using a blunt 22–25G cannula.
- Post-injection massage: After the injection, a facial massage is performed to distribute the product evenly and stimulate collagen production.
Aftercare Tips Following Sculptra
- Follow the “Triple 5” massage technique: 5 times a day, 5 minutes each time, for 5 consecutive days.
- Avoid makeup, sauna, steam treatments, and applying cream to injection sites for 24 hours.
- Stay out of direct sunlight and UV exposure until swelling and redness subsides.
- Wait 2–4 weeks before undergoing other facial procedures
How Much Does Sculptra Cost?
The price of one vial of Sculptra (10 CC) is approximately 30,000 THB. Actual prices may vary depending on clinic promotions.
Interested in getting Sculptra at V Square Clinic?
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Is Sculptra Safe?
Sculptra has been used for collagen stimulation since 1999 and is approved by the U.S. FDA. Numerous research studies support its safety and effectiveness. When used appropriately by trained professionals, Sculptra is a safe, non-harmful treatment.
Precautions Before Getting Sculptra
Avoid Sculptra if:
- You are pregnant or breastfeeding
- You are allergic to any ingredients (PLLA, CMC, or mannitol)
- You have autoimmune conditions (e.g., lupus, rheumatoid arthritis)
- You are taking immunosuppressive medications
- You have a history of severe allergic reactions (anaphylaxis)
- You have active skin infections or inflammation at the injection site
Possible Side Effects of Sculptra
Common temporary side effects include mild swelling, redness, or soreness at the injection site, which usually resolve within 2–3 days. Some patients may notice small lumps under the skin initially—these typically subside with proper massage as advised by the physician.
How Soon Will I See Results from Sculptra?
Changes may begin to appear around the third week after injection. Full results typically appear by the third month and can last up to two years.
How Many Sculptra Sessions Are Needed?
- For mild concerns: 1 vial per session, repeated 3 times at monthly intervals
- For more advanced aging or for patients aged 30 and above: 2 vials per session may be recommended
How Long Do Sculptra Results Last?
After 2–3 initial sessions, collagen continues to build, and results last around 2 years.
For one-time treatments without repeat sessions, effects typically last 2–4 months.
How to Spot Authentic Sculptra.
Genuine Sculptra should have:
- A monogram sticker on the box (intact, unopened)
- An embossed “S” symbol on the front of the box
- Thai-language documentation with an FDA registration number
- A scannable QR code (eZTracker app) for verification
- A vacuum-sealed vial with powder form (no liquid)
Summary – Sculptra: A Deep-Structural Approach to Skin Rejuvenation
Sculptra is a PLLA-based injectable that stimulates collagen production to lift and firm the skin from within. Its natural, long-lasting results make it a trusted choice. With both U.S. FDA and Thai FDA approval, it’s a safe treatment when performed by licensed professionals at certified clinics using authentic products.
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