Profhilo – A BioRemodeling Innovation to Revitalize Skin Structure
Profhilo is part of a new wave of Collagen Biostimulators gaining popularity for its unique Hybrid Cooperative Complex (HCC). This technology is designed to stimulate collagen production and rejuvenate skin quality from within, without altering your natural facial contours.
This article explains how Profhilo works, who it’s suitable for, and how it compares to other collagen-stimulating treatments—helping you evaluate whether this approach aligns with your skin goals.
Table of Content : Profhilo
What Is Profhilo? The Skin Rejuvenation Star Everyone’s Talking About
Profhilo is a Collagen Biostimulator treatment that uses a high concentration of hyaluronic acid (HA) to restore and restructure the skin (a process known as BioRemodeling). Unlike traditional fillers, it doesn’t add volume or drastically change facial features. Instead, it improves skin texture, hydration, firmness, and overall radiance while softening fine lines and acne scars. It’s ideal for those seeking a holistic skin rejuvenation approach.
What sets Profhilo apart is its HA concentration of 32 mg/ml, which is higher than most fillers or Skin Booster products on the market. It’s processed using patented NAHYCO® technology, which combines high and low molecular weight HA under controlled temperatures to form a stable Hybrid Cooperative Complex (HCC). This structure allows the HA to disperse evenly, last longer, and more effectively stimulate collagen production.
How Profhilo Works
After injection, Profhilo spreads uniformly across all skin layers—epidermis, dermis, and subcutaneous tissue. It targets and activates different types of skin cells:
- Keratinocytes (in the epidermis): Promote skin cell turnover, making the skin look brighter and fresher.
- Fibroblasts (in the dermis): Stimulate collagen and elastin production, improving elasticity and skin strength.
- Adipocytes (in the subcutaneous layer): Help replenish fat cells, giving the skin a plump, youthful appearance—often referred to as “baby fat.”
Why Isn’t Profhilo Classified as a Filler?
While both Profhilo and dermal fillers contain HA as their main ingredient, their mechanisms, intended outcomes, and treatment timelines differ significantly.
Traditional filler treatments use Crosslinked HA, in which chemical agents like BDDE are used to bond the molecules into a stable gel. This allows fillers to stay precisely at the injection site—whether it’s to volumize hollow cheeks or temples, smooth fine lines or deep wrinkles, enhance lips, or hydrate the skin for a dewy look.
Filler is ideal for patients looking to reshape the face or target deep-set lines and folds, or simply to boost skin hydration.
Profhilo, on the other hand, uses Non-Crosslinked HA that has undergone advanced technology to merge small and large HA molecules into a Hybrid Cooperative Complex (HCC). This allows for even distribution throughout all skin layers. The goal is not to volumize but to restructure the skin, activating the cells responsible for firmness, hydration, and elasticity.
Which One to Choose—Profhilo or Filler? If the primary concern is skin quality—such as hydration, elasticity, and firmness—Profhilo may be sufficient. However, for concerns involving deep facial hollows from bone or fat loss, or for targeted contouring, a dermal filler may be more appropriate.
Who Is Profhilo Suitable For?
Profhilo can be a great option for individuals across various age groups—starting from 25 years old up to the 40s and beyond—especially those who are experiencing early signs of skin aging or who want to enhance their overall skin quality. It’s ideal for:
- Individuals with dehydrated, dull, or dry skin who struggle to retain moisture
- Those with early fine lines who want to improve skin firmness and structure
- People with mild to moderate skin laxity or reduced skin elasticity
- Those looking to refine surface texture, minimize pores, acne scars, or minor imperfections
- Anyone wanting to rejuvenate skin health without changing facial structure
- People interested in preventative skincare to slow down skin aging
Where Can Profhilo Be Injected?
Profhilo is commonly injected into the face and neck, helping to improve skin texture, firmness, and reduce wrinkles, acne scars, and uneven tone. There is also Profhilo Body, which targets areas prone to sagging, such as the abdomen, upper arms, and knees, for firmer, more youthful-looking skin.
When Will Profhilo Show Results? Profhilo Reviews and Skin Transformation
Improvements can typically be seen within 7–14 days after injection. The skin often becomes more hydrated, radiant, and revitalized. Full results develop in 1–2 months, with visible improvement in elasticity, moisture retention, and a reduction in fine lines and wrinkles.
Review of Profhilo Results at V Square Clinic
Before-and-after comparison: Profhilo neck treatment, 14 days post-injection, using 1 syringe (2 CC)
Left: Frontal view – Right: Side view
How Many CCs and Sessions Are Needed for Profhilo to Work?
Each Profhilo syringe contains 2 cc. Depending on the skin condition and treatment area, a treatment session will typically use 1–2 syringes (2–4 cc). For optimal results, 2 sessions spaced 1 month apart are usually recommended. A third session may be beneficial for those with more advanced skin concerns or acne scarring.
Another crucial factor in Profhilo treatments is the experience of the injector. Profhilo is administered using a standardized injection technique called BAP (Bio Aesthetic Points)—5 points per side of the face and 10 points across the neck. This ensures even product distribution and maximum effectiveness.
How Long Do Profhilo Results Last? Maintenance and Touch-Up Guidelines
After completing 2 sessions within 1 month, Profhilo results typically last between 6–12 months, depending on the skin condition and lifestyle. For maintenance, a touch-up is generally recommended once a year, or as advised by a physician.
Is Profhilo Painful?
The discomfort is minimal and well-tolerated. Profhilo involves only 10 injection points with superficial depth and small volumes per point. A topical numbing cream is applied beforehand to enhance comfort.
Is Profhilo Safe? Are There Any Side Effects?
Profhilo is considered a safe treatment. The product is free from chemical cross-linking agents, which significantly reduces the risk of irritation. It is approved by both the European CE and Thai FDA. When performed by a trained medical professional in a licensed clinic, side effects are usually mild, such as temporary swelling, small bumps, or bruising at the injection sites, which typically resolve within 5–7 days.
How Much Does Profhilo Cost?
Profhilo typically costs around 25,000 THB per box (one syringe = 2 cc). This amount is usually sufficient for a full-face skin rejuvenation treatment in most cases. Pricing may vary slightly depending on the clinic.
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Is Profhilo Better Than Other Collagen Biostimulators?
Each Collagen Biostimulator has its strengths and is suitable for different skin conditions. Profhilo stands out for its ability to restore skin elasticity, firmness, and smoothness, while also enhancing moisture retention, without altering facial structure. Below is an overview of each product’s key benefits and ideal use cases to help clarify how they compare.
Sculptra
Sculptra is one of the first and most well-known collagen stimulators. Its main ingredient, PLLA (Poly-L-lactic acid), promotes the production of Type I collagen—the most abundant type found in the skin—by up to 66.5%. This strengthens the deeper skin layers, lifts sagging skin, and adds volume for a fuller, firmer appearance. Results can last up to 2 years.
Sculptra is ideal for individuals with deep wrinkles, sagging jawlines (double chin), or volume loss due to collagen depletion.
Radiesse Filler
Radiesse uses CaHA (Calcium Hydroxylapatite Microspheres), a substance naturally found in bones. Once injected, it directly stimulates fibroblast activity, encouraging the formation of five types of new collagen structures. It’s great for those who want to strengthen their skin, improve elasticity, boost hydration, and achieve a radiant, rosy complexion, while also adding volume to the face.
Gouri
Gouri contains PCL (Polycaprolactone), which stimulates neocollagenesis—the formation of new collagen beneath the skin. This process increases skin thickness, plumpness, and elasticity, while softening fine lines. It’s especially suitable for those seeking a “glass skin” effect or individuals experiencing collagen loss in the face, neck, or hands.
Juvelook
Juvelook is a Hybrid Biostimulator composed of PDLLA and non-crosslinked HA. It provides both immediate hydration and long-term collagen stimulation. Juvelook is commonly used to rejuvenate the entire face, reduce fine lines, improve skin texture, and tighten pores. It can also be injected around the eyes to reduce dark circles and crow’s feet.
Ultracol 200
Ultracol 200 uses PDO microspheres with ultra-fine, water-dispersible particles. These are safe to inject into delicate areas like the under-eyes, forehead, nasolabial folds, neck, and hands. It stimulates both Type I and Type III collagen, making it ideal for improving skin elasticity, reducing wrinkles, and enhancing overall radiance.
Before deciding whether to choose Profhilo or any other Collagen Biostimulator, it’s essential to consult with a medical professional. A personalized facial and skin assessment will help determine the most appropriate treatment based on individual goals and expectations.
Patients who visit V Square Clinic will receive a facial assessment and consultation with a doctor before undergoing any procedure. The consultation is free of charge.
Where to Get Profhilo? How to Choose a Safe Aesthetic Clinic
Since Profhilo is still relatively new in Thailand, not many clinics currently offer it. Before undergoing treatment, be sure to select a clinic with a valid medical license and a physician who has been formally trained in Profhilo injection techniques. Also, always verify that the product used is authentic and properly sourced.
Summary – Is Profhilo Worth It?
Profhilo is an excellent choice for individuals seeking to enhance skin texture, elasticity, and hydration. It can also be combined with other procedures—such as dermal fillers or other collagen stimulators—for enhanced results.
Ultimately, the best treatment depends on your skin concerns and aesthetic goals. It is strongly recommended to consult with a qualified physician who can assess your skin and develop a personalized treatment plan for optimal results.
Reference
- Cassuto D, Delledonne M, Zaccaria G, Illiano I, Giori AM, Bellia G. Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int. 2020 Jun 20;2020:8159047. doi: 10.1155/2020/8159047. PMID: 32685528; PMCID: PMC7327616.
- https://www.profhilo.co.uk/
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