Mesotherapy – A Fast-Acting Skin Rejuvenation Treatment
Mesotherapy is a skin treatment that involves injecting a cocktail of vitamins and beneficial extracts directly into the skin. This method helps revitalize dull and damaged skin, deeply hydrate, reduce inflammation, eliminate toxins, and strengthen the skin barrier.
This article will explain in depth what mesotherapy is, how it works to brighten your skin, whether it’s safe, who it’s suitable for, what it costs, and what precautions you should know before the procedure.
Table of Content : Mesotherapy
What Is Mesotherapy?
Mesotherapy is a skin treatment designed to deliver active ingredients—especially those that are hard to absorb through topical creams—directly into the middle layer of the skin (the dermis). This approach allows for faster, more noticeable effects, with visible improvements often appearing within one week after treatment.
The injection stimulates collagen production in the dermal layer, helping to restore firmness and give the skin a naturally radiant look—similar to the glow and plumpness of a fresh apple.
What Does the Word “Meso” Mean?
The term “meso” is derived from the word “mesoderm,” which refers to the middle layer of the skin where the treatment is targeted.
The dermis, or true skin layer, contains collagen, elastin, connective tissues, and hyaluronic acid—all of which are essential for skin elasticity and strength.
With age and environmental exposure, these structural components gradually decline, leading to dullness, sagging, and loss of elasticity.
Injecting mesotherapy into this layer helps nourish and revitalize the skin structure directly, resulting in healthier, stronger skin.
What Are the Benefits of Mesotherapy?
- Detoxifies skin from harmful substances such as allergens and pollutants, reducing rashes and acne
- Brightens the complexion and reduces melanin production
- Hydrates the skin, improves skin barrier function
- Reduces dark spots and melasma, and helps minimize pores
- Boosts collagen and elastin for firmer, more elastic skin
Is Mesotherapy Safe?
Mesotherapy is considered safe when performed correctly. The formula typically contains natural extracts and skin-nourishing vitamins based on the principles of homeopathy. These ingredients are designed to improve immunity and skin resilience.
When authentic, FDA-approved products are administered by an experienced doctor in a certified clinic, serious side effects are unlikely.
The primary risks come from counterfeit products or improper administration methods, such as:
- DIY meso kits
- Home injections
- Buying products online from unverified sources
These may cause allergic reactions, rashes, thinning skin, photosensitivity, or even infections. Treatment should always be performed by qualified professionals.
Types of Mesotherapy – What Are the Options and How Do They Differ?
There are several types and brands of mesotherapy available. When categorized by treatment goals, they generally fall into three main groups:
- Brightening & Hydration : These formulas aim to brighten dull skin and boost hydration. They often contain vitamins such as Vitamin A, B, C, E, and Transamin
- Strengthening & Repairing the Skin Barrier : This type helps balance the skin and improve moisture retention. Key ingredients include collagen and coenzymes, which help plump up the skin and tighten pores.
- Acne & Inflammation Control : These formulas focus on reducing acne, rashes, and inflammation by detoxifying the skin and calming oil glands. One of the standout options in this category is MADE Collagen.
Which Mesotherapy Brand Is the Best?
Because each person’s skin is unique, the most effective way to determine the appropriate mesotherapy formula is through a professional skin assessment. The right mesotherapy formula will be customized by the doctor based on the patient’s skin type and concerns.
Below are some of the most popular mesotherapy brands:
- MADE Collagen : Detoxifies the skin, reduces acne and rashes, restores skin balance
- Filorga : Brightens skin tone, reduces melasma, deeply nourishes and hydrates
- Revs : Stimulates collagen production, anti-inflammatory, enhances skin radiance
- Tensonez : Lightens dark spots, improves skin clarity, and hydration
- Neo-Glutanex Glow : Reduces freckles, acne marks, and fine lines, revives dry and dull skin
- Alpha Arbutin : Specifically formulated for reducing melasma
- Neoclear : Inhibits melanin production, fades melasma, freckles, and pigmentation
- Neoderm : Reduces inflammation, fades red and dark spots
At V Square Clinic, we perform a detailed skin evaluation before every mesotherapy session to ensure each patient receives the most suitable formula for their skin needs.
Injection Techniques – Mesotherapy Micro-Injection vs. 16-Point Method
Micro-Injection Technique (Traditional Mesotherapy)
This is the original mesotherapy technique, in which the product is injected in small amounts across the entire face using a fine needle.
The benefit of this method is that it not only delivers nutrients but also stimulates collagen production due to the micro-injuries caused by the needle.
However, there are some potential downsides. The treatment may cause bruising or redness, and if not performed hygienically, it can lead to inflammation or infection. This risk is significantly higher in cases where individuals attempt self-injection using unverified products purchased online.
16-Point Injection Technique (Lymphatic-Based Method)
Developed in Italy, the 16-point technique involves injecting along the lymphatic drainage pathways of the face.
Compared to the traditional micro-injection method, this technique offers several advantages, including reduced bruising, minimal discomfort, and longer-lasting results due to its targeted delivery.
Rather than distributing the product evenly across the entire face, this approach places the solution near the lymph nodes—the “source”—allowing it to gradually diffuse throughout the skin. As a result, the effects tend to be more sustained than those achieved with the traditional technique.
Does Mesotherapy Hurt?
Mesotherapy injections typically cause only mild discomfort if numbing cream is not applied beforehand.
In most cases, numbing is not required because the injection depth is shallow, the amount of product is minimal, and the procedure is quick. A simple cold compress before injection is usually enough to reduce sensitivity.
How Long Do the Effects of Mesotherapy Last?
The results of mesotherapy typically last between 1–2 months, especially when the treatment is performed consistently.
To help prolong the results, patients are advised to maintain a proper skincare routine and avoid habits that may damage the skin, such as excessive sun exposure, sleep deprivation, alcohol consumption, and smoking.
Can Mesotherapy Help with Oily Skin, Large Pores, or Melasma?
Mesotherapy can help improve oily skin and reduce the appearance of large pores. Sebaceous glands naturally produce oil to keep the skin hydrated.
When collagen is injected into the skin, it helps regulate oil production. As a result, the skin becomes less oily, and pores (excluding those caused by acne scarring) may appear smaller over time.
Can Mesotherapy Treat Melasma?
In cases of melasma, mesotherapy can help slow its progression and fade pigmentation by around 20–50%, depending on the individual’s condition.
Melasma occurs when melanocytes overproduce melanin, creating brown patches on the skin. It’s a protective response triggered by factors like sun exposure or allergic reactions.
Currently, no treatment—including Pico laser, topical creams, oral medication, or injections—can completely cure melasma. Most approaches aim to control or lighten the pigmentation, though some types of melasma may respond poorly to treatment.
How Long Before You See Results from Melasma Mesotherapy?
The rate of improvement from mesotherapy for melasma depends on the severity of the condition and the consistency of treatment.
A single session is typically not sufficient to produce clearly visible results. A course of 5 sessions is generally recommended to maintain results and accelerate pigmentation reduction. Gradual improvement is usually noticeable within 7-14 days.
What Are the Side Effects of Mesotherapy?
Mesotherapy is generally safe, as the injected substances typically consist of skin-nourishing ingredients such as vitamins that support skin resilience. The formula is biodegradable and leaves no residue in the body.
Common side effects are mild and temporary. These may include small needle marks at the injection sites or slight swelling and raised bumps, which usually subside as the solution is absorbed into the skin. Such effects resolve on their own within 1-3 days and are not harmful.
What to Do If a Red Rash Develops After Mesotherapy?
A post-treatment rash can have several causes. Below is how to identify and handle each case:
- Inflammation or infection
- Symptoms usually don’t appear immediately, but worsen around day 3 after treatment.
- If treated early with antibiotics, this condition is fully curable.
- To prevent recurrence, ensure strict hygiene during all future mesotherapy injections.
- Allergic reaction to numbing cream or meso ingredients
- Redness and swelling appear immediately after treatment and affect all injected or numbed areas.
- If the allergy is mild, it often resolves overnight.
- If swelling persists beyond 24 hours, consult your doctor for oral medication.
- Pre-existing skin condition flare-up
- Some rashes may be unrelated and appear coincidentally after treatment.
- Rashes in this category usually do not follow the injection points.
- Consult your doctor for a proper diagnosis and treatment plan.
- Needle-related bruising or trauma
- Appears as purple or greenish marks at or near the injection sites.
- May occur immediately or within 2–3 days.
- Apply a cold compress for the first 48 hours, followed by warm compresses as advised by your doctor.
How Long Does It Take to See Results from Mesotherapy? How Often Should You Get It?
Initial results from mesotherapy are typically noticeable within 3 days, with full results becoming visible between days 7–14.
For best outcomes, mesotherapy is usually administered once a week during the first month, then maintained every 2 weeks afterward.
It’s important to note that mesotherapy is not permanent—the solution is fully absorbed and leaves no residue in the body.
Is Mesotherapy Worth It? Who Is It Suitable For?
Mesotherapy delivers nutrients directly into the skin through targeted injections. Whether it is considered worthwhile depends on the individual’s skin condition and specific concerns.
Some patients may respond quickly to treatment, while others require multiple sessions to achieve noticeable results. A professional skin assessment is recommended to determine the most appropriate formulation and treatment plan.
Mesotherapy is generally suitable for:
- Those who don’t consistently use skincare products and want quicker results than creams can provide
- Individuals with busy lifestyles—those who stay up late or work long hours
- Patients looking for fast results may opt for more frequent sessions (e.g., every 3 days)
Are There Alternatives to Mesotherapy for Skin Brightening?
For individuals seeking quick improvements in skin brightness, hydration, and overall restoration, several advanced medical treatments are available that can complement or serve as alternatives to mesotherapy.
The most appropriate option depends on the individual’s skin type and specific goals, and a personalized consultation is recommended to determine the best treatment plan.
Consult your doctor for a detailed facial and skin evaluation.
Botox for Skin Brightening
Beneath the skin, there are tiny fibrous bands that connect to the underlying muscle layer. As collagen and fat decrease with age—typically after the age of 20—these fibers begin to pull more strongly on the skin, leading to the appearance of fine lines and uneven texture.
Injecting botulinum toxin into specific facial muscles can reduce this tension, allowing the surface of the skin to appear smoother and more radiant, thereby enhancing overall skin clarity and glow.
Skin Booster
In Western countries, “Skin Booster” typically refers to a skin-quality filler like Restylane Vital Light, a form of hyaluronic acid (HA) that’s more concentrated and hydrating than standard mesotherapy.
It’s more fluid than typical fillers, allowing it to spread widely and evenly across the skin layers. This makes it a great option for those looking to treat sagging, fine lines, and dullness, all at once.
Today, there are several notable Skin Booster brands available, such as:
- Belotero Revive – contains HA + Glycerol
- Skinvive by Juvederm – an advanced version of Juvederm Volite
HIFU
HIFU (High Intensity Focused Ultrasound) uses focused sound waves—rather than light—so it doesn’t damage the skin surface. Instead, it heats the deeper dermis, causing it to contract and tighten. It also stimulates collagen production, leading to firmer, smoother skin.
To visualize it simply, it’s like pulling a pillowcase tight to smooth out a pillow.
The two most widely used and trusted HIFU devices today are HIFU Ultraformer III and HIFU Ultraformer MPT. Both offer comparable lifting results, but the Ultraformer MPT features an Ultra Booster cartridge (a specialized treatment head) designed specifically for skin rejuvenation—enhancing skin clarity, smoothing texture, and minimizing pores.
Rejuran Injections
Rejuran is an injectable skin rejuvenation treatment using Polyneucleotide (PN), a DNA extract derived from salmon. It works at the dermal level, promoting a more even skin tone, reducing acne scars and pigmentation, and improving radiance and smoothness—often referred to as “glass skin” or dewy skin.
Does Topical Mesotherapy Work?
“Topical mesotherapy” is commonly used as a marketing term for certain creams or serums available online. In practice, these products function similarly to standard skincare and require consistent use over time for the active ingredients to be absorbed.
Unlike injectable mesotherapy, topical formulations do not penetrate the dermis, resulting in slower and less noticeable outcomes.
What to Watch Out for When Getting Mesotherapy?
There are many mesotherapy brands that are not approved by the Thai FDA, making it hard to verify their origin and ingredient safety.
For example, products containing steroids or hormones may produce rapid results—such as visibly whiter or softer skin—but long-term use over one to two years can lead to skin thinning, melasma, sun sensitivity, and premature aging.
Before undergoing mesotherapy, it is important to:
- Check the brand name of the product being used
- Verify it’s a genuine, legally imported product
To verify authenticity:
- Matching Lot Numbers on all packaging components
- Scan the QR Code on the box
- Ensure the seal is intact, with no signs of tampering
What to Avoid After Getting Mesotherapy?
Mesotherapy does not require downtime, and patients can return to normal activities immediately. However, there are some precautions to help reduce irritation and maximize the results:
- Avoid pressing or massaging the treated area during the first 1–2 nights
- Do not apply skincare products or creams directly on injection sites for the first night
- Avoid direct sunlight and pollution, and use broad-spectrum sunscreen daily
- Refrain from habits that harm the skin, such as alcohol consumption and smoking
- Avoid fried, greasy, fermented, or overly spicy food
- Drink at least 2 liters of water per day to keep the skin hydrated and promote healing
If redness, bruising, or mild soreness occurs at the injection sites, over-the-counter pain relievers and cold compresses may be used, as advised by your doctor.
Where to Get Mesotherapy Injections?
Before deciding to undergo mesotherapy, it’s important to do some research and choose a reputable clinic—one that is fully licensed and legally registered.
The clinic should:
- Have experienced doctors performing the treatment
- Provide clear, personalized consultations
- Offer fair and transparent pricing
- Allow patients to inspect the product packaging before each injection
Mesotherapy products approved by the Thai FDA can only be legally imported and sold to licensed doctors. Any mesotherapy sold online without prescription is typically unregulated or smuggled, and may be unsafe.
At V Square Clinic, we perform a thorough facial assessment before every treatment and customize the mesotherapy formula to match each patient’s skin condition, ensuring the best possible results.
How Much Does Mesotherapy Cost?
V Square Clinic offers both single-session and package pricing options for mesotherapy, with prices varying based on the specific formula used.
During consultation, the doctor will explain:
- The benefits of each formula
- Which one is best suited to the patient’s specific skin concerns
- How many sessions are recommended for optimal results
Interested in mesotherapy at V Square Clinic? Click here to view our latest promotions.
Summary – Skin Rejuvenation with Mesotherapy
Mesotherapy is a great option for those looking to revitalize their skin quickly. It helps brighten the complexion, even out skin tone, reduce acne, melasma, dark spots, and deeply hydrate the skin. It delivers faster results than skincare products alone, especially when the formula is carefully matched to your specific skin concerns.
However, to ensure both safety and effectiveness, it’s essential to:
- Get a professional skin assessment from a qualified doctor
- Use only authentic, FDA-approved products
- Receive treatment at a reputable, licensed clinic.
What Is Pico Laser? Everything You Need to Know Before Treating Melasma, Freckles, Dark Spots, Ac...
Reading Time: 11 minutesPico Laser is an advanced laser technology designed to address various pigmentation issues such as melasma, freckles, dark spots, acne marks, and acne scars. It works by targeting pigment particles in the skin at an ultra-fast speed,
What Is Sculptra? How Much Does It Cost? How Does It Stim...
Reading Time: 8 minutesSculptra is an advanced skin rejuvenation treatment that works from within by boosting collagen production. It restores firmness and smoothness to aging or sagging skin, offering a youthful appearance. This method is becoming increasingly popular
What Is Belotero Filler and Where Can It Be Injected?
Reading Time: 4 minutesBelotero is a genuine hyaluronic acid-based filler brand from Switzerland, officially imported to Thailand by Merz Healthcare (Thailand) Co., Ltd. It is registered with the FDA in the US, Europe, and Thailand. Belotero offers a range of formulas tailored for different facial areas to ensure optimal results.
What Is Volnewmer? Key Features, Who It’s For, and How Mu...
Reading Time: 8 minutesIs Skin Vitamin Injection really effective? Can it make your skin glow and look healthier? In recent years, Skin Vitamin Injections have become increasingly popular among individuals looking to improve their complexion quickly. Many people choose this method to achieve a radiant, even-toned look while also supporting immune health. Among the most commonly used ingredients is Vitamin C, which is believed to deliver fast and noticeable results.
Skin Vitamin Injection – Is It Safe? Where to Get It? How...
Reading Time: 7 minutesIs Skin Vitamin Injection really effective? Can it make your skin glow and look healthier? In recent years, Skin Vitamin Injections have become increasingly popular among individuals looking to improve their complexion quickly. Many people choose this method to achieve a radiant, even-toned look while also supporting immune health. Among the most commonly used ingredients is Vitamin C, which is believed to deliver fast and noticeable results.
What Is Rejuran? How Does It Brighten Skin and Shrink Por...
Reading Time: 10 minutesRejuran is a medical aesthetic innovation that rejuvenates the skin and enhances skin texture and clarity. It is clinically proven, certified by the Thai FDA, and supported by multiple scientific studies. Its popularity has grown significantly in recent years, especially among those desiring radiant, glass-like Korean skin.
