Exosome
Exosomes are gaining significant attention in the aesthetics field for their role in skin rejuvenation and repair. They are being applied to address multiple skin concerns such as wrinkles, enlarged pores, acne scars, melasma, freckles, and dark spots.
Medical research has confirmed their effectiveness in stimulating fibroblast cells, which play a key role in producing collagen and elastin. This process restores skin firmness and elasticity, making the skin look more youthful and revitalized.
Table of content : exosome
What Is Exosome?
Exosome refers to over 1,000 types of biomolecules, including growth factors, peptides, amino acids, coenzymes, hyaluronic acid, and various proteins. These biomolecules are naturally secreted from stem cells in the form of pure exosomes. They are tiny, spherical vesicles measuring only 30–100 nanometers — about 1/1,000 the size of a normal cell.
One of the most recognized exosome applications in aesthetics is ASCEplus SRLV Exosome. Due to their extremely small size — even smaller than PM 2.5 particles — exosomes can effectively penetrate cells and stimulate cellular activity, resulting in deep skin rejuvenation and repair.
Where Do Exosomes Come From?
ASCEplus Exosome originates from South Korea and is developed by ExoCoBio Inc., the first cosmeceutical and biopharmaceutical company to research and advance exosome technology. Using its patented ExoSCRT™ process, the molecules are refined to a smaller size with high bioavailability, improving skin absorption and treatment effectiveness. In Thailand, official distribution is handled by Aesthetics by Ampex, a trusted supplier of medical and beauty products.
Today, multiple brands of exosomes are available. For example, ASCE+ Exosome is derived from rose stem cells (Rose Stem Cell Exosome). Research shows it can stimulate collagen, reduce melasma, regulate melanin production, and minimize inflammation. Its main components include lipids, microRNA (miRNA), proteins, and growth factors. With quality control covering particle size, composition, purity, and cell-based testing, the outcomes consistently show positive results in skin rejuvenation.
Key Components of Exosome
Exosomes contain more than 1,000 biomolecules that contribute to skin repair and rejuvenation. Important examples include:
- Growth factors: Proteins that stimulate new cell formation and repair damaged cells.
- Epidermal Growth Factor (EGF): Stimulates collagen, elastin, and hyaluronic acid production, improving skin elasticity.
- Fibroblast Growth Factors (FGF): Promote superoxide dismutase (SOD), a natural antioxidant that delays aging.
- Peptides: Amino acid chains that boost skin cell regeneration and function. These include glutathione, a powerful antioxidant peptide that helps reduce dark spots, dullness, and fine lines.
- Amino acids: Essential for cell synthesis, enhancing skin firmness, hydration, and collagen production.
- Coenzymes: Support cellular functions and act as antioxidants, protecting skin from sun-induced damage and delaying wrinkle formation.
- Hyaluronic acid (HA): Encourages new cell growth, strengthens the skin barrier, and provides hydration for plump, supple, and smooth skin.
Research Related to Exosome
Several international studies have highlighted the effectiveness of exosome skin treatments:
- Skin rejuvenation: Improves youthfulness and tightens pores
- Acne scar revision: Reduces acne scars, post-acne dark spots, and redness
- Chronic inflammation/hypersensitivity: Calms skin irritation and rashes
- Wound healing: Promotes tissue repair and reduces scar formation
- Pigmentation regulation: Treats melasma, freckles, and dark spots
- Atopic dermatitis: Eases itching and skin inflammation caused by allergic reactions
- Anti-aging: Tightens skin and reduces wrinkles
Exosome therapy has also been applied in scalp treatments, specifically ASCEplus HRLV Exosome, which stimulates hair growth and addresses hair loss or thinning without surgical transplantation.
Additionally, studies on exosomes and cancer suggest their potential as biomarkers for early diagnosis and monitoring cancer progression, since exosomes can be isolated from blood, urine, saliva, and other body fluids.
In acne scar treatment, Korean laboratory research demonstrated that combining exosome therapy with laser treatment significantly improved scar healing. Results were effective across all scar types — ice pick, boxcar, and rolling scars — with the most visible improvements seen in rolling scars.
Which Areas Can Be Treated with Exosome?
Exosome therapy can be applied to multiple areas of the face and body, depending on the patient’s concerns. Common treatment areas include:
- Face: Helps reduce wrinkles, acne scars, dark spots, melasma, and enlarged pores.
- Under-eye area: Improves dullness, fine lines, and under-eye hollows.
- Neck: Restores elasticity and smoothness, reducing sagging.
- Scalp: Stimulates hair growth, reduces hair thinning and hair loss.
- Hands and body: Improves overall skin texture, hydration, and brightness.
With its ability to deliver growth factors and biomolecules directly to target cells, exosome therapy supports deep skin repair and rejuvenation across different areas.
Is Exosome Treatment Worth It?
For those focused on skin rejuvenation, there are many methods available today. Exosome therapy is unique because it encapsulates the highest-quality growth factors inside vesicles that mimic a cell membrane. This allows direct delivery into target cells with nearly 100% absorption, bypassing traditional barriers. As a result, exosomes effectively stimulate skin repair and renewal, leaving the complexion smoother, brighter, and healthier — making it one of the most advanced options available today.
How Many Brands of Exosome Are There?
Several exosome brands are now available in Thailand, giving doctors a range of options. Popular choices include ASCE Plus, Exocode, Exoxe, P198 ExoHealer, and Bnv Exo.
Each brand differs in production technology, stem cell source, key components, particle size, concentration, biological activity, and therapeutic applications.
So, which brand is the best? At V Square Clinic, we use ASCE Plus, produced under strict standards and quality control to ensure both safety and reliable results.
How Does Exosome Work?
As explained earlier, exosomes contain biomolecules that act as messengers between cells, transmitting signals to regulate essential cellular functions. They travel between skin cells and deliver instructions to repair, regenerate, or protect against damage.
The biomolecules carried by exosomes activate key skin processes such as:
- Stimulating fibroblasts to produce collagen and elastin.
- Enhancing antioxidant activity to fight free radicals that damage skin cells.
- Supporting cell metabolism and delaying skin cell degeneration.
Exosomes can also act as delivery vehicles, carrying therapeutic substances directly into target cells. This function makes them highly effective in tissue repair, wound healing, and cell regeneration.
What Are the Benefits of Exosome?
- Reduces wrinkles, firms and tightens skin, improves elasticity, and prevents new wrinkles.
- Inhibits melanin production, reducing melasma, freckles, dark spots, and post-acne marks.
- Brightens the complexion, boosts hydration, and plumps the skin for a dewy glow.
- Smooths skin texture, fades scars, reduces acne marks, and improves acne scars.
- Minimizes pore size for smoother-looking skin.
- Strengthens the skin barrier, calms inflammation, reduces acne, and improves sensitive skin.
Who Is Exosome Suitable For?
- People with wrinkles such as crow’s feet, forehead lines, or smile lines.
- Those with melasma, freckles, dark spots, or post-acne marks.
- Individuals with acne, including inflammatory acne on the cheeks, forehead, or chin.
- Patients with shallow acne scars, acne marks, or other facial scars.
- Those with enlarged pores, rough or uneven skin texture, dryness, or lack of hydration.
Individuals with dull, tired-looking skin lacking brightness and vitality.
Who Is Not Suitable for Exosome?
- Pregnant or breastfeeding women.
- Patients with cancer.
- Those allergic to flower pollen.
- Individuals taking immunosuppressive medications.
- Patients with autoimmune diseases.
How Is Exosome Different from Rejuran?
Before exosome became popular, Rejuran was already well-known in skin rejuvenation. Originating from Korea, it is an injectable treatment that strengthens the skin barrier, boosts radiance, and creates the “glass skin” effect.
So, what are the key differences between exosome and rejuran? For those considering skin rejuvenation, here is a comparison:
- Active substances: Exosome contains over 1,000 biomolecules including growth factors, peptides, and HA, while Rejuran is based on polynucleotides (PN) extracted from salmon DNA.
- Highlights: Exosome excels in deep cellular repair, reducing pigmentation, and supporting overall skin health. Rejuran is strong in rapid skin barrier repair, hydration, and glow.
- Suitable for: Exosome is ideal for patients with aging signs, pigmentation, acne scars, or dull skin. Rejuran suits those seeking quick recovery, hydration, and skin resilience.
- Time to see results: Both require multiple sessions, but patients may notice glow and hydration faster with Rejuran, while Exosome shows progressive improvements in scars, pigmentation, and skin texture.
- Longevity of results: Both provide long-lasting improvements with proper maintenance, though exosome offers broader benefits in anti-aging and skin regeneration.
| Treatment | Exosome | Rejuran |
|---|---|---|
| Main Components | Biomolecules from stem cells, such as growth factors, peptides, amino acids, coenzymes, and hyaluronic acid | Pure Polynucleotide (PN) 2% extracted from salmon DNA |
| Key Benefits | Skin rejuvenation — improves wrinkles, enlarged pores, acne scars, melasma, freckles, and dark spots | Restores youthful skin, brightens skin tone, and tightens pores |
| Suitable For | Individuals with wrinkles, melasma, freckles, dark spots, acne, acne scars, enlarged pores, rough texture, dryness, or dull skin | Individuals with dull or tired-looking skin, fine lines, enlarged pores, or shallow acne scars |
| Time to See Results | Visible in 3 days; recommended 3–5 sessions (sessions 1–3 every 2 weeks, session 4 after 1 month, session 5 after 1 year) | Visible in 3–5 days; recommended 4 sessions spaced 2–3 weeks apart |
| Duration of Results | 1 session lasts ~1 month; 2–3 sessions last 3–6 months; 5 sessions last up to 1 year | 1 session lasts ~1 month; 4 continuous sessions last up to 6 months |
Exosome Compared to Other Treatments
Aside from exosome and rejuran, there are several other aesthetic treatments available in clinics to address different skin concerns:
Meso Brightening (Meso Face Therapy):
This involves injecting vitamins and nourishing substances directly into the skin, giving faster results compared to topical skincare. It is suitable for those with little time for self-care who want quick skin rejuvenation. Benefits include brightening the skin, detoxifying residual impurities, reducing inflammation and rashes, and strengthening the skin barrier. A well-known option is Made Collagen, which begins showing results in about 3 days, with full results visible within 7–14 days.
Dermal Fillers:
Fillers help replenish natural collagen, elastin, and hyaluronic acid that decline with age, leading to sagging, loss of elasticity, and premature aging. For skin improvement, specific filler types are recommended:
- Belotero Revive: Contains hyaluronic acid (HA) and glycerol to enhance skin in four dimensions: smoothness, plumpness, firmness, and hydration.
- Skin Booster Fillers: Lightweight, fine-textured fillers such as Restylane Vital Light or Juvederm Volite. Their strong water-retaining properties provide long-lasting hydration, improve dryness, restore radiance, minimize fine lines, tighten pores, and in some cases, treat shallow acne scars.
Skin Tightening Devices:
Energy-based treatments such as Hifu Ultraformer III, Ulthera SPT, and Thermage work by tightening and lifting the skin. They also stimulate collagen production, improving overall skin quality — leaving the skin firmer, pores smaller, wrinkles softened, and the complexion more youthful.
At V Square Clinic, our doctors carefully evaluate each patient’s skin condition and concerns before recommending the most suitable treatment.
Preparation Before Exosome Treatment
- Research essential information, including how to choose a certified clinic, a qualified doctor, proper techniques, and how to verify genuine exosome products.
- Avoid aspirin, NSAIDs, and supplements such as St. John’s Wort, Ginkgo Biloba, Primrose Oil, Garlic, Ginseng, and Vitamin E.
- Avoid laser treatments, hair removal, or shaving in the treatment area prior to the procedure.
- Stop using exfoliating products and avoid facial massages at least 3 days before treatment.
- Inform the doctor of any medical conditions or regular medications before treatment.
Exosome Treatment Procedure
- Cleanse the face and apply a topical anesthetic cream to minimize discomfort.
- Wait 30–45 minutes for the anesthetic to take effect.
- The doctor administers exosome into the skin.
- The procedure takes approximately 15–30 minutes.
- Small bumps may appear temporarily at the treatment sites, but these will subside as the solution is absorbed.
- No downtime is required; patients can resume normal daily activities immediately.
Aftercare Following Exosome Treatment
- Avoid touching, scratching, or massaging treatment sites if mild redness, swelling, bruising, or itching occurs; these symptoms usually improve within 2–3 days.
- Avoid massaging or pressing the treatment sites if soreness occurs during the first night.
- Use side pillows for the first 2–3 nights to prevent pressure on the face.
- Drink 1.5–2 liters of water daily (8–10 glasses).
- Avoid alcohol for at least 7–14 days.
- Avoid facial treatments or laser procedures that deliver heat energy for 7–14 days.
- Refrain from saunas or high-heat environments.
- Avoid strenuous exercise that may affect the treated area.
Precautions for Exosome Treatment
Exosome treatment must be performed by an experienced doctor who is familiar with proper techniques, and only genuine products should be used. Each box contains two vials — one blue vial of Lypophilized powder and one black vial of Diluent. The doctor mixes both vials to yield 5 cc per treatment. The package must be opened in front of the patient, and the box should be given to the patient afterward for verification.
Important precautions:
- Do not purchase exosome products sold online for self-use.
- Never undergo treatment from non-medical personnel, as proper dosage, technique, and treatment sites must be carefully managed to prevent unwanted side effects.
How Much Does Exosome Treatment Cost?
Exosome treatment starts at 9,xxx THB. It is available per session or in treatment courses, such as 3-session or 5-session packages. Choosing a package is usually more cost-effective, as the average price per session becomes lower.
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How Many CC of Exosome Are Needed?
For ASCE Plus Exosome, the standard dose is 5 cc (2 vials) per session, covering the entire face and extending to the neck area.
How Often Should Exosome Be Done?
The recommended treatment plan is as follows:
- Every 2 weeks for the first 3 sessions
- The 4th session after 1 month
- The 5th session after 1 year
How Long Does Exosome Last?
- 1 session: lasts about 1 month.
- 2–3 sessions: results last 3–6 months.
- 5 sessions: results last up to 1 year.
How Soon Can You See Results from Exosome?
Noticeable improvements are usually seen within 3 days. With a full course of 5 sessions, results can last up to 1 year, depending on individual skin condition and lifestyle factors.
Is Exosome Painful?
Pain is minimal with exosome treatment. A topical anesthetic is applied before treatment, ensuring comfort during the procedure. The treatment are generally not painful, and the session is quick and well tolerated.
How Long Does an Exosome Session Take?
Exosome treatment is straightforward and usually takes about 15–30 minutes, depending on the patient’s skin condition and treatment areas.
Summary
Exosome treatment is a powerful option for skin repair and rejuvenation. It improves overall skin quality, reduces melasma and pigmentation, enhances hydration and radiance, stimulates collagen and elastin production, minimizes pores, smooths acne scars, and strengthens skin cell regeneration.
For those seeking youthful, revitalized skin, a consultation with an experienced doctor is recommended. At V Square Clinic, we offer free online consultations directly with our doctors to help determine the best treatment plan.
References
- http://www.exocobio.com/bizdemo87737/eng/index.php
- http://www.asceplus.com/SRLV
- https://www.novusbio.com/research-areas/cell-biology/Exosome-research-tools
- https://medicaljournalssweden.se/actadv/article/view/1834/3865
- https://www.nstda.or.th/nac/2026/seminar/se14/
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