Understanding the Trend of Collagen Biostimulator Injections
Collagen Biostimulator injections continue to be a leading trend in aesthetics. Their key strength lies in stimulating natural collagen production, repairing damaged tissue, and restoring firmness, elasticity, and youthful smoothness — a result many people desire.
Looking to learn more about Collagen Biostimulators? This article offers a complete guide, covering what they are, the different types available, the benefits they provide, who may be an ideal candidate, and possible side effects. It also compares six leading brands — highlighting their differences, how to choose the right option, and typical treatment costs.
Table of Content : Collagen Biostimulator
What Are Collagen Biostimulators?
Collagen Biostimulators are substances that stimulate fibroblast cells to naturally produce new collagen and elastin in the skin. Unlike skin boosters, which mainly restore hydration in the dermis, Collagen Biostimulators work at a deeper level — repairing the underlying structure of aging skin and restoring firmness and youthfulness.
A key advantage of Collagen Biostimulators is that they go beyond short-term volumizing effects. They encourage the skin to generate collagen continuously for 1–2 years. These treatments are also internationally recognized for safety and efficacy, with approvals from both the US FDA and the Thai FDA.
What Is Collagen and Why Is It Essential for Youthful Skin?
Collagen is the body’s most abundant protein and serves as a key structural component of the skin, hair, bones, joints, and other tissues. It provides strength, elasticity, and firmness to the skin while also supporting tissue repair.
With age, collagen production gradually decreases. After 20, collagen levels in the skin decline by about 1% each year. From around 35 onward, production continues to drop — by 15%, 25%, and eventually 35% — leading to sagging skin, wrinkles, and reduced elasticity. Collagen Biostimulators help counter this process by stimulating the body to produce collagen naturally.
Types of Collagen Biostimulators
Currently, several types of Collagen Biostimulators are widely used, each with distinct properties suited to different skin concerns:
- PLLA (Poly-L-Lactic Acid): A biodegradable lactic acid polymer that gradually stimulates collagen production. It helps lift sagging skin and improve elasticity. The key ingredient in the popular product Sculptra.
- CaHA (Calcium Hydroxylapatite): A mineral similar to natural bone components, offering both volumizing and collagen-stimulating effects. The key ingredient in Radiesse filler.
- PDO (Polydioxanone): The same material used in dissolvable threads, focusing on lifting and structural rejuvenation. The key ingredient in Ultracol.
- PDLLA (Poly DL-Lactic Acid): A blend of PLLA with enhanced tissue dispersion properties, ideal for long-term rejuvenation such as acne scar treatment and pore reduction. The key ingredient in Juvelook.
- PCL (Polycaprolactone): A slowly biodegradable polymer, also used in dissolvable medical sutures, that rejuvenates aging skin and improves overall quality. The key ingredient in Gouri.
This article also includes a detailed comparison of the leading Collagen Biostimulator brands — highlighting their composition, texture, longevity, and specific advantages — to help patients better understand their options.
How Do Collagen Biostimulators Work?
Collagen Biostimulators work by stimulating the skin’s natural ability to produce collagen. Once injected, the substance acts as a biostimulant that signals fibroblast cells to generate new collagen and elastin fibers. The process can be summarized in four steps:
- Fibroblast activation: After injection (e.g., PLLA, CaHA, PDO, PDLLA, or PCL), the substance stimulates fibroblast cells to begin collagen synthesis.
- Natural collagen production: The body produces Type I and Type III collagen, which are vital for elasticity and firmness.
- Skin remodeling: Newly formed collagen rebuilds the skin’s structure, improving elasticity and reducing wrinkles, acne scars, and sagging.
- Long-lasting effects: The biostimulator gradually biodegrades, leaving behind only the body’s own collagen. This makes it suitable for those seeking long-term rejuvenation rather than short-lived results.
Benefits of Collagen Biostimulators
Collagen Biostimulators are distinguished by their ability to rejuvenate the skin from within by stimulating natural collagen production. This process helps restore youthful resilience and overall skin health. Key benefits include:
- Collagen stimulation in the deep dermis enhances elasticity, improves firmness, and lifts sagging skin
- Wrinkle reduction, from fine lines to deeper folds, by rebuilding skin structure and replenishing from within
- Skin repair from sun damage, pollution, and aging, leading to stronger and healthier skin
- Structural remodeling that smooths and refines skin texture at the cellular level
- Hydration replenishment and improvement in uneven skin tone for a brighter complexion
- Long-term skin rejuvenation restores quality and vitality in aging skin
Collagen Biostimulator Options: Which Brands Are Best?
Several Collagen Biostimulators are used in aesthetic medicine, each with unique components, mechanisms, and properties designed to address different skin concerns. The most recognized include:
1. Sculptra
Sculptra is known as the world’s first and original Collagen Biostimulator. It has been in medical use since 1999, supported by over 50 clinical studies, and is FDA-approved in both the United States (US FDA) and Thailand, ensuring safety and efficacy.
- Key ingredient: PLLA (Poly-L-Lactic Acid)
- Formulation: Dry powder reconstituted with sterile water before injection
- Properties: Gradually stimulates collagen production in deeper skin layers, enabling natural repair. Results are subtle and natural, lasting up to 2 years
- Best suited for: Patients with sagging skin who need facial lifting and deep structural rejuvenation
- Recommended sessions: 2–3 treatments, spaced 4–6 weeks apart
- Injection areas: Temples, jawline, midface
2. JuveLook
JuveLook is an innovative hybrid biostimulator combining PDLLA (Poly D,L-Lactic Acid) with Hyaluronic Acid (HA) in a single treatment. It is designed for deep rejuvenation, addressing multiple dimensions of skin health with results lasting up to 18 months.
- Key ingredients: PDLLA (Poly DL-Lactic Acid) blended with HA (Hyaluronic Acid)
- Formulation: Dry powder reconstituted with normal saline before injection
- Properties: Stimulates collagen production while HA provides immediate hydration, offering dual action for plump, radiant, and youthful-looking skin
- Best suited for: Fine wrinkles, dry skin, acne marks, pigmentation, and patients seeking brighter, smoother skin
- Recommended sessions: 3 treatments, spaced 4 weeks apart, with effects lasting 12–18 months
- Injection areas: Full face, neck, deep nasolabial folds, acne scars, facial depressions
3. Radiesse
Radiesse is a collagen-stimulating filler that also restores facial volume by targeting the deep dermal structure. It promotes regeneration of five key skin matrix components: Collagen Type I, Collagen Type III, elastin, angiogenesis (new blood vessel formation), and proteoglycans. Results last up to 2 years.
- Key ingredient: CaHA (Calcium Hydroxylapatite)
- Formulation: Pre-filled injectable gel, ready to use
- Properties: Fills deep wrinkles while stimulating collagen, ideal for reshaping facial contours, refining the jawline, and lifting the temples and cheeks
- Best suited for: Patients with facial volume loss, wrinkles, and decreased collagen who want youthful, firmer skin
- Recommended sessions: 1–3 treatments, spaced about 1 month apart
- Injection areas: Hollow cheeks, jawline, midface, nasolabial folds, marionette lines, hands
4. Neauvia
Neauvia is a filler classified as a Collagen Biostimulator — essentially a hybrid between a dermal filler and a collagen stimulator. Its key ingredients are non-cross-linked hyaluronic acid (HA) combined with 1% CaHA, making it ideal for patients who want both hydration and collagen stimulation in a single treatment. Results typically last 6–9 months.
- Key ingredients: Non-cross-linked HA with CaHA
- Formulation: Pre-filled injectable gel
- Properties: Provides instant hydration while stimulating collagen, improving skin smoothness, and overall quality
- Best suited for: Patients seeking smoother, more hydrated skin, reduction of fine lines, or rejuvenation of sagging neck skin
- Recommended sessions: 4 treatments, spaced 1 month apart
- Injection areas: Full face, neck, hands
5. Ultracol 200
Ultracol 200 is designed to stimulate collagen production and restore skin structure, helping to reduce wrinkles and refine texture. Results last around 6–8 months.
- Key ingredient: PDO (Polydioxanone)
- Formulation: Dry powder reconstituted with sterile water before injection
- Properties: Stimulates collagen formation and strengthens skin structure, suitable for acne scar repair and facial lifting
- Best suited for: Patients with skin laxity, acne scars, or those seeking smoother, firmer skin
- Recommended sessions: 3 treatments, spaced every 2 months
- Injection areas: Temples, under-eye area, nasolabial folds, marionette lines, jawline
6. Gouri
Gouri is a collagen stimulator based on polycaprolactone (PCL), a biodegradable polymer widely used in medical sutures. With a high concentration of 21% PCL, Gouri promotes collagen regeneration, firming, smoothing, and wrinkle reduction. Results last around 1 year.
- Key ingredient: PCL (Polycaprolactone)
- Formulation: Pre-filled injectable solution (1 syringe)
- Properties: Stimulates collagen production while brightening the skin, improving damaged or aging skin for a “glass skin” effect
- Best suited for: Patients seeking firmer, smoother, and more hydrated skin
- Recommended sessions: 1–3 treatments, spaced 1 month apart
- Injection areas: Full face, neck, hands
Collagen Biostimulators are available in several brands, each with unique properties suited to different concerns. Choosing the right option should be based on an individual’s skin condition, the desired duration of results, and a doctor’s professional recommendation to ensure both safety and effectiveness.
Possible Side Effects of Collagen Biostimulators
Most side effects after Collagen Biostimulator injections are temporary and resolve on their own within a few days. These may include:
- Swelling, redness, or bruising at the injection site, typically resolving within 2–7 days. A cold compress can help reduce swelling.
- Mild irritation or itching caused by the skin’s reaction to substances such as PLLA, CaHA, or PDO. These usually subside within 1–3 days.
- Small nodules or lumps at the injection site, which can often be improved with gentle massage.
Other, less common side effects include skin discoloration, persistent redness, worsening swelling, or pain. In such cases, patients should seek medical evaluation immediately.
Who Is Suitable for Collagen Biostimulators?
Collagen Biostimulators are designed to rejuvenate the skin from within by stimulating natural collagen production. They are suitable for:
- Adults over 25 with skin laxity and collagen loss
- Individuals with fine lines who want smoother skin texture
- Patients with acne scars and enlarged pores seeking improved elasticity
- Those wanting brighter, healthier-looking skin with a glass-skin glow
- Individuals seeking long-term improvement in skin quality through continuous collagen regeneration
- Patients who want subtle contouring in areas such as the temples, hollow cheeks, and the jawline
- Individuals with sensitive skin need repair and strengthening
Injection Areas for Collagen Biostimulators
Collagen Biostimulators can be injected into various areas of the body to restore collagen and address specific concerns, including:
- Face: Temples, nasolabial folds, marionette lines, jawline, under-eye area, hollow cheeks, acne scars
- Neck
- Hands
- Stretch marks or scars on the skin
The choice of Collagen Biostimulator brand should be based on the treatment area and individual skin concerns.
Precautions and Preparation Before Collagen Biostimulator Injections
Preparing for Collagen Biostimulator treatment is straightforward. Patients can follow these simple guidelines:
- Avoid anti-inflammatory medications such as aspirin, ibuprofen, or other NSAIDs for at least 7 days beforehand to minimize the risk of bruising or bleeding
- Avoid alcohol consumption for 24–48 hours before treatment
- Stop using skincare products with retinol, AHA, or BHA for at least 3–5 days before injection
- Do not undergo treatment if pregnant or breastfeeding
- Inform the doctor of any allergies, medical conditions, or ongoing medications
- Get adequate rest before the appointment so the body is in optimal condition for recovery
Collagen Biostimulator Injection Procedures
Collagen Biostimulator injections must be performed by experienced doctors in accredited clinics to ensure both safety and effective results. The procedure typically includes:
- Consultation and Treatment Planning
- The doctor carefully evaluates the patient’s skin condition
- Concerns and desired outcomes are discussed, such as wrinkle reduction, skin tightening, or facial contouring
- The most suitable Collagen Biostimulator type is selected (e.g., PLLA, CaHA, PDO, PDLLA, or PCL)
- Pre-Injection Preparation
- The treatment area is cleansed thoroughly to minimize infection risk
- A topical anesthetic is applied to reduce discomfort during the procedure
- Injection Process
- Specialized techniques are used to deliver Collagen Biostimulator into precise skin layers
- Pre-calculated doses are administered to achieve natural-looking, evenly distributed results
- Gentle massage during injection helps ensure smooth distribution of the product
- Post-Treatment Care
- After treatment, patients are advised to avoid sun exposure, massage of the treated area, and irritating skincare products
- Adequate hydration is recommended to support collagen regeneration
- Mild swelling, redness, or bruising may occur but usually subsides within 2–7 days
How Soon Can You See Results from Collagen Biostimulators?
Results from Collagen Biostimulator injections vary depending on the product type and each individual’s skin response.
Immediately after injection
- The skin feels more hydrated and plump, with slight improvement from hydrating components such as HA or CaHA that help retain moisture
Within 1–2 weeks
- Collagen production gradually begins, and the skin shows noticeable improvement in smoothness and elasticity
Most visible results
- Around 6–8 weeks post-treatment, the skin becomes firmer, smoother, and more lifted due to new collagen formation
- With long-acting stimulators like PLLA (Poly-L-Lactic Acid) or PCL (Polycaprolactone), results continue to improve for 3–6 months after injection
Collagen Biostimulators provide gradual but natural improvement with long-lasting results. Visible changes often appear within 1–2 weeks, with the most significant outcomes seen at 6–8 weeks. Final results depend on the product used and individual response, but proper aftercare under a doctor’s guidance can help maximize benefits and prolong results.
How Much Do Collagen Biostimulators Cost?
Collagen Biostimulator treatments generally range in the tens of thousands (THB). While the cost is higher compared to some other procedures, the long-lasting and natural results make it a worthwhile investment for patients seeking sustained skin rejuvenation.
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Can Collagen Biostimulators Be Combined with Other Treatments?
Yes. Collagen Biostimulators can be safely combined with other aesthetic procedures to enhance results and provide comprehensive skin rejuvenation. Examples include:
- Filler injections (e.g., Skinvive): For immediate correction of acne scars, deep folds, or volume loss in areas such as temples and nasolabial folds
- Botox: To reduce dynamic wrinkles from muscle activity, while Collagen Biostimulators improve skin structure and firmness
- Mesotherapy (Skin revitalizing injections): To deliver vitamins and nutrients into superficial skin layers, complementing deep collagen stimulation
- Skin Boosters (e.g., Rejuran, exosome): To hydrate and repair superficial skin, enhancing the long-term effects of Collagen Biostimulation
Note: Combination treatments should always be performed under a doctor’s recommendation to ensure safety and optimal results.
Summary : Are Collagen Biostimulators Worth It?
Collagen Biostimulators are highly effective for long-term skin rejuvenation, helping restore collagen at a deep level. The benefits include firmer, younger-looking, and healthier skin, with improvements in wrinkles, sagging, and dryness.
In summary, for those seeking natural, safe, and lasting facial rejuvenation, Collagen Biostimulator injections are truly worth considering.
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