
Picosure Pro — The Newest Generation Skin Laser
Picosure Pro is one of the most talked-about skin lasers today, offering solutions for multiple concerns such as melasma, freckles, dark spots, acne scars, wrinkles, and even tattoo removal. Compared with traditional skin rejuvenation lasers, it delivers faster results with fewer side effects. The device has also been upgraded from its previous version to work more efficiently and achieve visible outcomes more quickly.
This article will guide you through everything about Picosure Pro — how it works, its unique advantages compared with other skin lasers, post-treatment care, and important information to consider before choosing a clinic.
Table of Content : Picosure Pro
What Is Picosure Pro and What Problems Can It Treat?
Picosure Pro is the latest Picosecond Laser technology from Cynosure, USA. It is the only device on the market that uses a 755 nm wavelength, allowing precise penetration into the dermis layer of the skin. This makes it highly effective for treating pigmentation conditions such as melasma, Hori’s nevus, and nevus of Ota, while also brightening and smoothing the skin without harming surrounding tissues.
It is also the first Pico Laser officially approved by the U.S. FDA for treating melasma, freckles, and birthmarks on all skin types. With proven results and fewer side effects, it has become a trusted choice for a wide range of skin concerns, including:
- Treating melasma, deep freckles, nevus of Ota, Hori’s nevus, and post-acne dark spots
- Evening out skin tone and restoring natural radiance
- Refining skin texture, minimizing acne scars, and tightening pores
- Stimulating collagen to soften fine lines
- Safely removing dark tattoos in colors such as black, blue, green, purple, and brown.

How Does Picosure Pro Work?
Picosure Pro works in a similar way to other Picosecond Lasers. It delivers ultra-fast energy pulses in the picosecond range (one trillionth of a second) beneath the skin. These pulses effectively break down pigment particles and stimulate collagen production, leading to smoother, brighter, and more even-toned skin.
Here’s how Picosure Pro addresses different skin concerns in detail.
Watch the video to learn more about how Picosure Pro works
Treating Melasma, Freckles, Pigmented Lesions, and Tattoo Removal
Melasma, freckles, and pigmented birthmarks occur due to excess melanin in the skin, while tattoos are caused by ink pigments embedded in the dermis.
With its ultra-fast picosecond energy delivery, Picosure Pro breaks down these pigments into tiny particles that the body naturally eliminates. As a result, pigmentation fades, skin tone becomes more even, and tattoos lighten safely — without leaving external scars.
Improving Wrinkles, Large Pores, and Acne Scars
Picosure Pro also helps with wrinkles, enlarged pores, and acne scars by stimulating new collagen production.
A specialized Platinum Focus Lens is commonly used, concentrating the laser energy up to 20 times. When delivered into the skin, it creates microscopic bubbles called LIOB (Laser-Induced Optical Breakdown). This process triggers the skin’s natural repair mechanism, leading to the formation of fresh collagen — making the skin firmer, smoother, and more youthful.
What Are the Key Advantages of Picosure Pro?
Picosure Pro is the only Pico Laser on the market with a 755 nm wavelength, offering unique benefits such as:
- Penetrating the dermis — the layer where melasma, freckles, and permanent tattoo pigments are typically located
- Targeting melanin pigments with high efficiency, delivering visible results without requiring excessively high energy levels
- Minimal interaction with blood vessels, reducing the risk of pinpoint bleeding or bruising
- No wounds or peeling after treatment, enabling quick recovery and lowering the risk of PIH (post-inflammatory hyperpigmentation)
When compared with traditional skin lasers, many of those devices need much higher energy to treat pigmentation. This can lead to wounds, peeling, pinpoint bleeding, or prolonged redness, especially in individuals with thinner or darker skin who are more susceptible to PIH.
Picosure Pro vs. Picosure — What’s the Difference?
Picosure Pro is the upgraded generation of the original Picosure. Both use the same 755 nm wavelength and Picosecond Laser technology, but Picosure Pro introduces enhanced features for better flexibility, efficiency, and patient comfort. These updates allow shorter treatment sessions and fewer total visits.
Key improvements include:
- Higher energy delivery: Picosure Pro provides up to 300 mJ (vs. 200 mJ in the original), enabling faster and more effective treatments
- New clinical indications: It is the only Picosecond Laser approved by the U.S. FDA for melasma, nevus of Ota, and Hori’s nevus
- New handpiece: A 5 mm handpiece compatible with the Platinum Focus Lens for targeted treatment of delicate skin or small areas
- Turbo Mode: A new tattoo removal mode that enhances results and reduces the number of sessions needed
- Shorter treatment time: Requires 33% fewer shots per treated area, reducing session time from around 15 minutes to just 10 minutes
- Faster startup: Device warms up in only 11 minutes (vs. 20 minutes in the older version), allowing quicker procedures
- Modern design: Updated look with a sleek appearance and user-friendly graphic interface for greater convenience

Who Is Picosure Pro Suitable For?
Based on its features and mechanism, Picosure Pro is ideal for patients who:
- Have limited time for downtime and want minimal side effects compared with traditional skin lasers
- Desire a glass-skin effect with smooth, radiant, even-toned skin and refined pores
- Want to even out skin tone, reduce dullness, and lighten melasma and freckles
- Have a history of acne with post-acne dark spots, scars, or pitted marks
- Have facial birthmarks, pigmented lesions under the eyes, or deep freckles
- Wish to maintain a youthful look by stimulating collagen and reducing fine lines
- Need safe tattoo removal, especially for dark ink colors like black, blue, green, purple, and brown
How Many Sessions of Picosure Pro Are Needed?
Results from Picosure Pro can often be seen after the very first session. However, for longer-lasting and more noticeable improvement, it is generally recommended to undergo a course of 3–5 treatments.
The exact number of sessions and the interval between them depend on the skin condition, treatment mode, and individual response. Here is a general guideline:
- Freckles: For superficial freckles, results may be clear after 1–2 sessions using the scab-forming mode. Deeper freckles and sunspots usually require 3–5 sessions, spaced 2–6 weeks apart.
- Melasma: Shallow melasma may improve after 1–2 sessions, while deeper melasma in the dermis often requires 3–5 sessions. On average, melasma can improve by around 50%.
- Skin rejuvenation: For overall brightening, reducing fine lines, acne scars, and pores, about 5 sessions or more are recommended, repeated every 2–4 weeks.
- Tattoo removal: With its Turbo Mode, Picosure Pro usually requires about 5–6 sessions, depending on ink color, density, and depth. Sessions are typically spaced 6–8 weeks apart.

Current technology cannot completely cure melasma 100%, as it is influenced by multiple factors, including hormones, age, and UV exposure.
What to Know Before Choosing Picosure Pro
Before deciding where to undergo Picosure Pro treatment, patients should verify the clinic’s credibility and ensure the procedure is performed by qualified doctors. It is also important to know how to check whether the Picosure Pro Laser being used is genuine.
How to verify an authentic Picosure Pro Laser

Other key points include understanding what Picosure Pro feels like, whether it is painful, and how to properly prepare before treatment — all of which help minimize side effects.
What Does Picosure Pro Feel Like? Is It Painful?
During treatment, the sensation is often described as similar to a rubber band snapping against the skin. Some patients may feel mild discomfort, but it is generally well tolerated. Most clinics apply a topical numbing cream for 30–45 minutes beforehand, which greatly reduces pain. On a pain scale, it usually does not exceed 5 out of 10.
After treatment, a temporary warm or slightly burning sensation under the skin may be experienced for about 30 minutes, which gradually subsides. Many clinics provide cold compresses or soothing facial masks afterward to calm the skin and reduce heat.
How to Prepare Before Picosure Pro
To ensure the best outcome and minimize risks, patients should avoid other aesthetic procedures or treatments for about 2–4 weeks before undergoing Picosure Pro. Additional preparation includes:
- Providing a full medical history, including allergies, previous treatments, and a list of regular medications or supplements
- Applying sunscreen consistently, strengthening the skin barrier, and avoiding direct sun exposure for at least 1–2 weeks before treatment
- Using moisturizer to keep the skin hydrated and prevent dryness or peeling
- Avoiding medications or skincare products that promote skin exfoliation, such as retinol, AHA, and BHA, for at least 1 week before treatment
Post-Treatment Care After Picosure Pro Laser
After undergoing Picosure Pro, patients should be aware of possible side effects and follow proper aftercare to monitor their skin condition effectively.
How to Take Care of the Skin After Picosure Pro Laser
With standard Picosure Pro modes, side effects are usually minimal — most commonly mild redness or pinkish skin, without wounds or pinpoint bleeding. Recommended aftercare includes:
- Resume normal activities — cleansing and applying makeup are usually fine if no irritation occurs
- Apply moisturizer — choose gentle or medical-grade formulas, especially during the first week
- Protect the skin from UV exposure — use high-SPF, high-PA sunscreen, combined with hats or umbrellas
- Avoid exfoliating products such as retinol, AHA, or BHA for at least one week
For cases treated with the scab-forming mode, avoid washing the face on the first day; the brown scabs typically fall off naturally within 5–7 days. For the tattoo removal mode, avoid getting the treated area wet for 1–2 days to reduce infection risk.
Possible Side Effects of Picosure Pro and How to Manage Them
Side effects vary depending on the mode and energy level used:
- Redness or pinkish skin: Common and harmless, usually subsides within 24 hours (up to 48 hours for very sensitive skin). Cold compresses can help.
- Temporary darkening of melasma or freckles: Caused by pigment shattering into smaller fragments; these naturally fade within 24 hours.
- Small rashes or irritation: May occur if higher energy levels are used or if it is the patient’s first Pico Laser session. Applying TA cream thinly for 1–3 days usually helps.
- Blisters: Occasionally seen in tattoo removal cases. A doctor can safely drain the blister and manage the wound.
Side effects that should not occur include pinpoint bleeding. This may indicate improper technique or unsuitable energy settings. In such cases, avoid washing the face for 24 hours and seek immediate medical evaluation.
Why Choose Picosure Pro Laser at V Square Clinic?
At V Square Clinic, our Picosure Pro program uses only authentic, certified devices with verifiable sources. Every treatment is designed and performed by doctors with extensive experience in skin laser rejuvenation.
We also provide other premium laser technologies — such as Pico Plus, Discovery Pico, Fotona SP Dynamis, Bellalux Lite, and Sylfirm X Plus — to address a wide range of skin concerns, including melasma, freckles, pigmentation, acne scars, vascular lesions, and dull skin.

For first-time patients, our VSQ Laser Center provides detailed facial imaging scans before a direct consultation with our doctors. Post-treatment follow-up is scheduled every two weeks, allowing us to adjust treatment plans to ensure the best personalized results.


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Conclusion — Clear Results with Picosure Pro by Experienced Doctors
Picosure Pro is an excellent option for patients looking to address pigmentation concerns such as melasma, freckles, dark spots, acne marks, or birthmarks. It also rejuvenates the skin, leaving it smooth, radiant, and youthful — with no downtime and safe for all skin types.
At our VSQ Laser Center, every patient is treated with authentic, verifiable devices under the care of experienced doctors. From detailed facial scanning and thorough assessment to personalized treatment planning and close follow-up, we ensure that every patient achieves the best possible results with confidence.
References
- Tanghetti Md E, Jennings J. A comparative study with a 755 nm picosecond Alexandrite laser with a diffractive lens array and a 532 nm/1064 nm Nd:YAG with a holographic optic. Lasers Surg Med. 2018 Jan;50(1):37-44. doi: 10.1002/lsm.22752. Epub 2017 Nov 7. PMID: 29111604.
- https://aesla.com/picosure-pro-755nm-picosecond-laser-th/
- https://www.cynosurelutronicemea.com/product/picosure-pro/
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