Radiesse Filler: A Collagen-Stimulating Innovation That Rejuvenates and Revitalizes Your Skin in One Syringe

Reading Time: 12 minutes วันที่อัพเดตล่าสุด : 1 September 2025

Radiesse Filler

These days, healthy-looking skin is not just about appearing glowy or dewy on the surface. True skin health also refers to the integrity and resilience of the deeper layers of the skin structure.

Radiesse Filler is an advanced innovation in aesthetic medicine that enhances skin quality from within. It stimulates five key types of skin-supporting structures and delivers three powerful results—Healthier, Younger, and Longer—both instantly and over time. This makes Radiesse an ideal solution for those seeking long-term skin rejuvenation and a naturally youthful appearance.

Table of content : Radiesse Filler

• What Is Radiesse Filler ?
  • What is CaHA ?
  • Header T How Does Radiesse Filler Work?
  • How Many Types of Radiesse Filler Are There?
• Who Is Radiesse Filler Suitable For?
  • Who Should Avoid Radiesse Filler?
• Where Can Radiesse Filler Be Injected?
• What Are the Benefits of Radiesse Filler?
• How Much Does Radiesse Filler Cost?
• Comparing Radiesse Filler with Other Skin Rejuvenation Treatments
  • Radiesse
  • Sculptra
  • Gouri
  • Rejuran
  • Exosome
  • Skin Booster Fillers
• Where to Get Radiesse Filler Injections in Thailand?
• Post-Treatment Care After Radiesse Filler Injection
• Precautions After Radiesse Filler Injection
• Possible Side Effects After Radiesse Injection
• Frequently Asked Questions (FAQs)
  • How long does Radiesse Filler last?
  • How soon will I see results after a Radiesse injection?
  • How many sessions of Radiesse are needed?
  • How many cc are in one box of Radiesse Filler?
  • Summary

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What Is Radiesse Filler ?

Radiesse Filler is a regenerative treatment that restores skin health and structure. While it belongs to the family of dermal Fillers, Radiesse stands out from conventional HA (Hyaluronic Acid) Fillers. Instead of using HA, Radiesse’s main component is CaHA (Calcium Hydroxylapatite microspheres)—a biocompatible material researched and developed by Merz Aesthetics.

Since its launch in 2006, Radiesse has been trusted by practitioners in over 85 countries, with more than 15 million syringes used worldwide.

The uniqueness of Radiesse lies in its role as a Regenerative Biostimulator. Unlike typical Fillers that add volume, Radiesse actively encourages the skin to rebuild its internal support matrix by stimulating five key components.

• Collagen Type I
• Collagen Type III
• Elastin
• Angiogenesis (formation of new blood vessels)
• Proteoglycans (molecules that support skin hydration and structure)

These stimulate the following benefits.

• Healthier : Firmer, plumper, and more resilient skin with improved overall quality
• Younger : Visible reduction in fine lines and sagging, delivering a more youthful appearance
• Longer : Extended longevity of skin health and structural improvement

What is CaHA ?

CaHA (Calcium Hydroxylapatite) is a naturally occurring substance found in bones and teeth. The form used in Radiesse, however, is synthetically produced to ensure uniform particle size and purity. The resulting CaHA microspheres are smooth, spherical particles measuring 25–45 microns, designed to mimic what naturally exists in the body closely.

CaHA has been used in medical treatments for over 25 years. Its safety and efficacy are well-supported by more than 250 scientific publications and studies. It has received approval from the U.S. FDA and the CE Mark in Europe, making it a globally trusted and biocompatible solution. It does not trigger immune rejection and gradually biodegrades in the body without leaving any residue.

Note: Radiesse Filler is officially approved by three major regulatory bodies: the EU, the US FDA, and Thailand’s FDA. It is specifically certified for professional injection use, assuring both safety and reliability for clinical treatments.

How Does Radiesse Filler Work?

The mechanism behind Radiesse Filler involves injecting the product into the subdermal layer of the skin. Once injected, the CaHA particles stimulate the activity of fibroblasts—cells responsible for producing collagen. This kickstarts a natural regenerative process from within.

Following injection, the CaHA microspheres serve as a scaffold for collagen regeneration, forming what’s called a 3D matrix. This matrix supports the surrounding skin structure and encourages new collagen growth in deeper layers of the skin. The skin appears plumper and more rejuvenated right after the treatment.

In addition, CaHA also helps reverse signs of skin aging by stimulating elastin production—up to 250% more—enhancing skin elasticity and resilience. This not only improves skin texture but also helps slow the development of future wrinkles.

How Many Types of Radiesse Filler Are There?

There are two formulations of Radiesse Filler available:

1. Radiesse® – Standard formula without any anesthetic.
2. Radiesse® (+) – Contains lidocaine (a local anesthetic) to minimize discomfort during injection.

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Who Is Radiesse Filler Suitable For?

Radiesse Filler may be an excellent option for individuals with the following skin concerns :

• Those with loss of volume or collagen depletion in the face
• Deep facial folds such as nasolabial folds, marionette lines, or the corners of the mouth
• Sagging skin or poorly defined facial contours
• Dry, dull skin with enlarged pores or reduced hydration
• Wrinkles or age-related volume loss on the hands or neck
• Skin with mild acne scars, depressions, or shallow indentations
• Individuals aged 30 and above seeking to restore youthful skin, increase collagen, and prevent further aging

Who Should Avoid Radiesse Filler?

Radiesse Filler is not recommended for the following individuals:

• Those who are pregnant or breastfeeding
• Anyone with a history of severe allergic reactions or anaphylactic shock
• Individuals allergic to lidocaine or any ingredients in the Filler
• Those prone to keloid or hypertrophic scarring
• People with active skin infections or inflammation near the treatment area
• Individuals with bleeding disorders or on anticoagulant medications

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Where Can Radiesse Filler Be Injected?

Radiesse Filler is commonly used to correct facial folds and deep wrinkles, particularly in the following areas:

• Full face
• Mid-cheeks
• Nasolabial folds (laugh lines), marionette lines
• Backs of the hands

However, it is not recommended to inject Radiesse into the periorbital muscles, glabellar lines, nose, lips, or areas around the mouth. These areas are more sensitive and may respond better to other aesthetic procedures.

If you’re concerned about aging signs or volume loss in those zones, your doctor may recommend alternative treatments like targeted HA Fillers for a more precise and natural correction.

Here are some suggested treatments for those specific areas:

• Facial lifting with Fillers: Helps address facial sagging by volumizing mid-cheeks and smile lines, giving a lifted and more youthful look.
• Under-eye Fillers: Reduce under-eye hollows, dark circles, and puffiness for a refreshed, well-rested appearance.
• Nasolabial fold Fillers: Smooth out deep folds and sagging near the mouth. Advanced injection techniques can also help lift downturned mouth corners.
• Temple Fillers: Add volume to hollow temples, create facial harmony, and soften crow’s feet, making the overall facial appearance look more youthful and balanced.
• Forehead Fillers: Correct sunken or flat foreheads, improving facial proportions and softening the expression.
• Lip Fillers: Add volume and definition to the lips, correcting thin, dry, or asymmetrical lips for a more naturally plump and youthful smile.
• Chin Fillers: Improve a short, recessed, or asymmetrical chin, helping to sculpt a more defined V-shape facial profile.

Note: Each Filler area requires a different volume (cc), Filler formulation, and brand. The choice of which brand and type of Filler to use will depend on your skin condition and aesthetic goals. A qualified doctor will guide you in choosing the most suitable product to ensure the best, safest, and most satisfying results.

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What Are the Benefits of Radiesse Filler?

Radiesse Filler is well-known for its collagen-stimulating properties and long-lasting rejuvenation effects. Here are the key benefits it offers:

• Stimulates Type I Collagen production by +150%: Enhances the skin’s structural integrity, acting as foundational support for new skin cells. This results in firmer, tighter skin.
• Stimulates Type III Collagen production by +130%: Reorganizes collagen and elastin fibers in deeper layers of the skin, especially in connective tissue. This helps reduce fine lines, improve skin firmness, and add volume.
• Increases Elastin production by +260%: Significantly improves the skin’s elasticity and resilience, making it look more youthful and supple.
• Promotes angiogenesis (formation of microvessels): Enhances blood flow and nutrient delivery to skin cells, improving skin tone and vitality.
• Stimulates the production of proteoglycans (natural skin moisturizers): Helps the skin retain moisture, making it hydrated, elastic, and more responsive to natural repair processes.

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How Much Does Radiesse Filler Cost?

The price of Radiesse Filler varies depending on the clinic, the ongoing promotions, and the number of cc (syringe volume) required for your treatment. At V Square Clinic, the current promotion for Radiesse is 2 syringes for approximately 5x,xxx THB.

Before any treatment, patients are welcome to receive a free consultation. The doctor will assess your skin condition and recommend the most suitable approach based on your individual needs—with no obligation or additional cost.

Interested in Radiesse Filler injections at V Square Clinic ? Click to see our latest promotions.

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Comparing Radiesse Filler with Other Skin Rejuvenation Treatments

In today’s aesthetic field, there are several collagen-stimulating injectables designed to improve skin quality from within. Among the most popular options are Radiesse, Sculptra, and Gouri. In addition, treatments such as HA-based skin boosters, Rejuran, and Exosome injections are also widely used for deep skin rejuvenation at the cellular level.

Radiesse

Radiesse Filler is a collagen biostimulator that focuses on restoring facial volume while improving skin structure.

• Main Ingredient: CaHA (Calcium Hydroxylapatite), a substance naturally found in the human body, making it safe, biocompatible, and gradually biodegradable.
• Mechanism: Stimulates the regeneration of 5 key skin components—Collagen Type I, Collagen Type III, Elastin, Angiogenesis, and Proteoglycans.
• Best for: Individuals aged 30+ with loss of facial volume, collagen depletion, or age-related wrinkles who are looking to restore youthful firmness.
• Results Timeline: Immediate plumping is visible after injection. Noticeable skin tightening and elasticity begin within 1 month. Full results appear within 3–6 months.
• Longevity: Up to 2 years

Sculptra

Sculptra is a collagen-stimulating injectable that emphasizes skin structure renewal over volumization.

• Main Ingredient: PLLA (Poly-L-Lactic Acid)
• Mechanism: Stimulates Type I collagen synthesis by up to 66.5%, improving skin firmness, volume, and elasticity. It also helps reduce skin laxity and improves overall texture.
• Best for: Individuals aged 25+ seeking to rebuild internal skin structure, prevent age-related skin sagging, and maintain a youthful appearance over time.
• Results Timeline: After injection, PLLA begins to activate within 5 days. Visible results in 2–3 weeks, with continued improvement over the next 3 months.
• Longevity: Up to 2 years

Gouri

Gouri is a next-generation collagen booster designed to revive aging and damaged skin and enhance overall skin health.

• Main Ingredient: PCL (Polycaprolactone) in a fully liquid form
• Mechanism: Stimulates fibroblast activity to produce collagen and elastin, resulting in improved skin hydration, reduced pore size, firmer texture, and fewer fine lines.
• Best for: Individuals aged 18+ with early signs of aging, skin laxity, or those seeking natural collagen enhancement without adding volume like traditional Fillers.
• Results Timeline: Noticeable improvements appear within 1–2 weeks after treatment.
• Longevity: 6 to 12 months

Rejuran

Rejuran belongs to the Skin Booster category, designed to deeply hydrate and revitalize the skin, giving it a naturally plump and radiant “glass skin” appearance.

• Main Ingredient: PN (Polynucleotide) derived from salmon DNA
• Mechanism: Stimulates collagen, elastin, and fibroblast activity to repair skin at the cellular level—strengthening the skin barrier, enhancing moisture retention, and boosting natural radiance.
• Best for: Individuals aged 18+ with dry, damaged, or dull skin, uneven tone, hyperpigmentation, or acne scars who are looking for quick and natural skin rejuvenation.
• Results Timeline: Visible improvement begins within 2–5 days; clearer, more radiant skin in about 4 weeks.
• Longevity: 3–6 months, depending on skincare routine and lifestyle

Exosome

Exosome therapy is a Skin Booster treatment that repairs damaged skin at the cellular level.

• Main Ingredients: Over 1,000 bioactive molecules, including proteins, nucleic acids, and lipids
• Mechanism: Restores healthy skin function, reduces inflammation and acne, boosts hydration and elasticity, tightens pores, and improves texture.
• Best for: Individuals with acne-prone skin, shallow scars, large pores, dull or dehydrated skin, or skin that reacts easily to external stimuli.
• Results Timeline: Visible improvements within 3–7 days; best outcomes after 5 consecutive sessions
• Longevity: Up to 1 year, depending on the patient’s skin condition and aftercare

Skin Booster Fillers

Skin booster Fillers use Hyaluronic Acid (HA) to hydrate and rejuvenate the skin, targeting dryness, roughness, and fine lines without significant volumization.

• Main Ingredient: Hyaluronic Acid or HA (Except for Belotero Revive, which combines HA with glycerol for enhanced hydration)
• Popular Brands and Models: Juvederm Volite, Restylane Vital Light, Belotero Revive
• Mechanism: Delivers deep hydration, improves elasticity, smooths skin texture, and minimizes pores and fine lines.
• Best for: Individuals with dehydrated or rough skin, large pores, uneven texture, or early signs of aging—such as forehead lines, under-eye hollows, or marionette lines.
• Results Timeline: Instant improvement after injection, with full results in 2 weeks
• Longevity: 6–12 months, depending on Filler brand and post-treatment care

Each procedure has distinct ingredients, mechanisms, benefits, and timelines, making it suitable for different skin concerns. If you’re unsure which treatment is best for you, it’s strongly recommended to consult a medical professional. A proper skin evaluation will help select the most suitable and targeted solution for your needs.

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Where to Get Radiesse Filler Injections in Thailand?

Radiesse injections should always be administered by a licensed and experienced physician who has received formal training from Merz Aesthetics Thailand. This ensures the correct techniques are used, especially in preparing and mixing the product before injection.

When choosing a clinic, here’s what you should look for:

• A legally registered clinic with a visible license number from the Ministry of Public Health.
• A displayed list of certified practitioners
• Use of genuine Radiesse Filler, which patients can verify using the steps below:
  • Thai FDA registration number
  • A QR code on the box that links to the official Radiesse verification system
  • Matching lot numbers on both the outer box and the internal packaging
  • Inclusion of an official Skin Rejuvenation Card or Radiesse Club Card
  • You can also confirm the lot number with the exclusive distributor, Merz Healthcare Thailand, by calling 02 026 1111

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Post-Treatment Care After Radiesse Filler Injection

After receiving Radiesse Filler, it’s common to experience mild swelling, which typically subsides within 72 hours. Proper aftercare helps ensure optimal results and minimizes side effects. Here are some recommendations:

• Avoid touching, rubbing, or applying pressure to the treated area.
• Refrain from applying makeup for at least 12 hours, or until injection marks have fully healed.
• Avoid high-heat treatments (e.g., lasers, radiofrequency), and stay out of saunas for at least 2 weeks.
• If small lumps or nodules appear under the skin, gentle massage may help reduce them.
• Bruising may occur, as Radiesse is usually injected across multiple facial zones.
• For redness or swelling, cold compresses and oral or topical anti-bruising medications can help.
• After the first 24 hours, warm compresses may be applied (as advised by your physician).
• If any unusual symptoms occur, consult your physician promptly.
• Inform your healthcare provider before undergoing any additional treatment in the same area where Radiesse was injected.

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Precautions After Radiesse Filler Injection

Although Radiesse is a safe treatment, there are still a few things to be cautious about during the initial recovery period:

• You may resume daily activities as usual.
• Avoid touching, scratching, or massaging the face vigorously, as the injection sites may still be healing.
• If the skin becomes red or sensitive, apply a cold compress and take any prescribed medications to reduce bruising.
• After 24 hours, switch to a warm compress as instructed by your physician.

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Possible Side Effects After Radiesse Injection

It’s normal to experience minor side effects after a Radiesse injection, such as redness or bruising at the injection site. These symptoms typically resolve within 1 to 3 days.

However, if you notice more unusual symptoms, such as:

• Skin discoloration
• Pale or whitened skin in the treated area

These may indicate abnormal vascular reactions and should be evaluated by a physician immediately to ensure proper management and avoid complications.

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Frequently Asked Questions (FAQs)

How long does Radiesse Filler last?

Radiesse can deliver visible results for up to 2 years, depending on how frequently it’s administered and how well the patient cares for their skin post-treatment. Proper skincare helps preserve the newly formed collagen for longer-lasting benefits.

How soon will I see results after a Radiesse injection?

Radiesse offers immediate volume restoration after injection. Within the first month, you’ll start to notice firmer, tighter skin with improved elasticity and reduced appearance of wrinkles or folds. The collagen-stimulating effects of CaHA become more pronounced between 3 to 6 months, gradually lifting and volumizing the skin for a more youthful appearance.

How many sessions of Radiesse are needed?

For optimal, long-lasting results, it is generally recommended to receive 1–3 sessions of Radiesse, spaced at least 1 month apart. The number of sessions may vary depending on each patient’s skin condition and desired outcomes. A consultation with your physician will help determine the most appropriate treatment plan.

How many cc are in one box of Radiesse Filler?

Each box of Radiesse Filler contains one pre-filled syringe wit.5 cc of product. The Filler has a shelf life of 2 years and can be stored at 15–25°C without refrigeration.

Each syringe contains:

• 30% CaHA (Calcium Hydroxylapatite) microspheres – Uniform, spherical particles ranging from 25–45 microns
• 70% CMC (Carboxymethylcellulose) gel carrier

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Summary

Radiesse Filler is more than just a skin-smoothing treatment—it works deep within the dermal structure to stimulate collagen and elastin production. This leads to firmer, more elastic, and more hydrated skin, with gradual improvement over time.

It is a highly effective non-surgical option for individuals seeking to restore facial volume, reduce visible signs of aging, and maintain a naturally youthful appearance. Before undergoing treatment, it is important to understand how Radiesse works, what results to expect, and how to care for your skin afterward.

Having this knowledge will help you make a well-informed and confident decision about your skin health.

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